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| 04.05.2021 | 14:00 | AC Pisa | - | Venezia FC | 2:2 (2:0) | |
| 14:00 | AS Cittadella | - | Virtus Entella | 1:0 (0:0) | ||
| 14:00 | Chievo Verona | - | US Cremonese | 1:1 (1:0) | ||
| 14:00 | Delfino Pescara | - | AC Reggiana 1919 | 1:0 (1:0) | ||
| 14:00 | Empoli FC | - | Cosenza Calcio | 4:0 (2:0) | ||
| 14:00 | Vicenza Virtus | - | Brescia Calcio | 0:3 (0:2) | ||
| 14:00 | Pordenone Calcio | - | US Salernitana 1919 | 1:2 (0:1) | ||
| 14:00 | Reggina 1914 | - | Ascoli Calcio | 2:2 (1:1) | ||
| 14:00 | SPAL 2013 Ferrara | - | Frosinone Calcio | 0:1 (0:0) | ||
| 14:00 | AC Monza | - | US Lecce | 1:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Empoli FC | 36 | 18 | 16 | 2 | 66:32 | 34 | 70 |
| 2 |
|
US Salernitana 1919 | 36 | 17 | 12 | 7 | 41:34 | 7 | 63 |
| 3 |
|
US Lecce | 36 | 16 | 13 | 7 | 65:43 | 22 | 61 |
| 4 |
|
AC Monza | 36 | 16 | 13 | 7 | 48:31 | 17 | 61 |
| 5 |
|
Venezia FC | 36 | 15 | 12 | 9 | 52:38 | 14 | 57 |
| 6 |
|
AS Cittadella | 36 | 15 | 11 | 10 | 47:32 | 15 | 56 |
| 7 |
|
Brescia Calcio | 36 | 13 | 11 | 12 | 55:50 | 5 | 50 |
| 8 |
|
Chievo Verona | 36 | 12 | 14 | 10 | 44:36 | 8 | 50 |
| 9 |
|
SPAL 2013 Ferrara | 36 | 12 | 14 | 10 | 41:41 | 0 | 50 |
| 10 |
|
Reggina 1914 | 36 | 12 | 13 | 11 | 40:39 | 1 | 49 |
| 11 |
|
Frosinone Calcio | 36 | 11 | 13 | 12 | 33:41 | -8 | 46 |
| 12 |
|
US Cremonese | 36 | 11 | 12 | 13 | 43:43 | 0 | 45 |
| 13 |
|
AC Pisa | 36 | 10 | 15 | 11 | 48:53 | -5 | 45 |
| 14 |
|
Vicenza Virtus | 36 | 10 | 14 | 12 | 45:51 | -6 | 44 |
| 15 |
|
Pordenone Calcio | 36 | 9 | 14 | 13 | 38:39 | -1 | 41 |
| 16 |
|
Ascoli Calcio | 36 | 10 | 11 | 15 | 35:45 | -10 | 41 |
| 17 |
|
Cosenza Calcio | 36 | 6 | 17 | 13 | 29:42 | -13 | 35 |
| 18 |
|
AC Reggiana 1919 | 36 | 9 | 7 | 20 | 29:53 | -24 | 34 |
| 19 |
|
Delfino Pescara | 36 | 7 | 11 | 18 | 29:54 | -25 | 32 |
| 20 |
|
Virtus Entella | 36 | 4 | 11 | 21 | 27:58 | -31 | 23 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
