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| H | Club Necaxa | - | CF América | 0:2 | ||
| R | CF América | - | Club Necaxa | 0:0 | ||
| H: 02.05.2018 16:00 | R: 05.05.2018 16:00 | Sieger: CF América | ||||
| H | CF Pachuca | - | Deportivo Guadalajara | 2:0 | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||
| H: 02.05.2018 16:30 | R: 05.05.2018 16:00 | Sieger: CF Pachuca | ||||
| H | Pumas UNAM | - | Santos Laguna | 2:3 | ||
| R | Santos Laguna | - | Pumas UNAM | 2:3 | ||
| H: 03.05.2018 17:00 | R: 06.05.2018 16:00 | |||||
| H | UANL Tigres | - | Gallos Blancos | 2:0 | ||
| R | Gallos Blancos | - | UANL Tigres | 2:1 | ||
| H: 03.05.2018 17:00 | R: 06.05.2018 17:00 | Sieger: UANL Tigres | ||||
