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| H | Deportivo Toluca | - | CF Pachuca | 1:1 (0:1) | ||
| R | CF Pachuca | - | Deportivo Toluca | 1:0 (1:0) | ||
| H: 31.03.2010 04:00 | R: 08.04.2010 02:00 | Sieger: CF Pachuca | ||||
| H | Pumas UNAM | - | Cruz Azul | 1:0 (1:0) | ||
| R | Cruz Azul | - | Pumas UNAM | 5:0 (1:0) | ||
| H: 01.04.2010 04:00 | R: 07.04.2010 04:00 | Sieger: Cruz Azul | ||||
