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| 25.09.2021 | 13:30 | Chelsea FC | - | Manchester City | 0:1 (0:0) | |
| 13:30 | Manchester United | - | Aston Villa | 0:1 (0:0) | ||
| 16:00 | Everton FC | - | Norwich City | 2:0 (1:0) | ||
| 16:00 | Leeds United | - | West Ham United | 1:2 (1:0) | ||
| 16:00 | Leicester City | - | Burnley FC | 2:2 (1:2) | ||
| 16:00 | Watford FC | - | Newcastle United | 1:1 (0:1) | ||
| 18:30 | Brentford FC | - | Liverpool FC | 3:3 (1:1) | ||
| 26.09.2021 | 15:00 | Southampton FC | - | Wolverhampton Wanderers | 0:1 (0:0) | |
| 17:30 | Arsenal FC | - | Tottenham Hotspur | 3:1 (3:0) | ||
| 27.09.2021 | 21:00 | Crystal Palace | - | Brighton & Hove Albion | 1:1 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Liverpool FC | 6 | 4 | 2 | 0 | 15:4 | 11 | 14 |
| 2 |
|
Manchester City | 6 | 4 | 1 | 1 | 12:1 | 11 | 13 |
| 3 |
|
Chelsea FC | 6 | 4 | 1 | 1 | 12:2 | 10 | 13 |
| 4 |
|
Manchester United | 6 | 4 | 1 | 1 | 13:5 | 8 | 13 |
| 5 |
|
Everton FC | 6 | 4 | 1 | 1 | 12:7 | 5 | 13 |
| 6 |
|
Brighton & Hove Albion | 6 | 4 | 1 | 1 | 8:5 | 3 | 13 |
| 7 |
|
West Ham United | 6 | 3 | 2 | 1 | 13:8 | 5 | 11 |
| 8 |
|
Aston Villa | 6 | 3 | 1 | 2 | 9:7 | 2 | 10 |
| 9 |
|
Brentford FC | 6 | 2 | 3 | 1 | 8:5 | 3 | 9 |
| 10 |
|
Arsenal FC | 6 | 3 | 0 | 3 | 5:10 | -5 | 9 |
| 11 |
|
Tottenham Hotspur | 6 | 3 | 0 | 3 | 4:9 | -5 | 9 |
| 12 |
|
Watford FC | 6 | 2 | 1 | 3 | 7:9 | -2 | 7 |
| 13 |
|
Leicester City | 6 | 2 | 1 | 3 | 7:10 | -3 | 7 |
| 14 |
|
Wolverhampton Wanderers | 6 | 2 | 0 | 4 | 3:5 | -2 | 6 |
| 15 |
|
Crystal Palace | 6 | 1 | 3 | 2 | 6:9 | -3 | 6 |
| 16 |
|
Southampton FC | 6 | 0 | 4 | 2 | 4:7 | -3 | 4 |
| 17 |
|
Newcastle United | 6 | 0 | 3 | 3 | 7:14 | -7 | 3 |
| 18 |
|
Leeds United | 6 | 0 | 3 | 3 | 6:14 | -8 | 3 |
| 19 |
|
Burnley FC | 6 | 0 | 2 | 4 | 5:11 | -6 | 2 |
| 20 |
|
Norwich City | 6 | 0 | 0 | 6 | 2:16 | -14 | 0 |
| Champions League | |
| Europa League | |
| Europa Conference League Quali. | |
| Abstieg |
