| 23. Spieltag | 22.01.2022 | Virtus Entella | - | AS Gubbio | 4:0 | ||||
| 24. Spieltag | 30.01.2022 | AS Gubbio | - | US Grosseto FC | 0:0 | ||||
| 21. Spieltag | 02.02.2022 | Fermana FC | - | AS Gubbio | 1:1 |  |
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| 27. Spieltag | 16.02.2022 | US Pontedera | - | AS Gubbio | 0:0 | ||||
| 28. Spieltag | 20.02.2022 | AS Gubbio | - | SSD Città di Teramo | 2:2 | ||||
| 22. Spieltag | 23.02.2022 | AS Gubbio | - | AC Reggiana 1919 | 2:1 | ||||
| 29. Spieltag | 27.02.2022 | Carrarese Calcio | - | AS Gubbio | 1:0 | ||||
| 30. Spieltag | 06.03.2022 | AS Gubbio | - | Vis Pesaro | 3:0 | |
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| 31. Spieltag | 12.03.2022 | ACN Siena 1904 | - | AS Gubbio | 1:2 | |
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| 32. Spieltag | 15.03.2022 | AS Gubbio | - | Imolese Calcio | 2:1 | |
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| 33. Spieltag | 19.03.2022 | Lucchese | - | AS Gubbio | 2:2 | ||||
| 34. Spieltag | 27.03.2022 | AS Gubbio | - | Viterbese | 1:2 | |
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| 36. Spieltag | 09.04.2022 | AS Gubbio | - | US Pistoiese | 2:2 | |
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| 37. Spieltag | 14.04.2022 | AS Gubbio | - | Modena FC | 1:1 | ||||
| 38. Spieltag | 23.04.2022 | Aquila Montevarchi | - | AS Gubbio | 2:1 |  |
Italien