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| 06.04.2022 | 13:00 | FK Skopje | - | KF Shkupi | 0:0 (0:0) | |
| 15:00 | FK Bregalnica Štip | - | FK Rabotnički | 0:3 (0:1) | ||
| 15:00 | FK Renova | - | Makedonija GP | 0:1 (0:0) | ||
| 15:00 | FK Pelister | - | KF Shkëndija 79 | 0:2 (0:0) | ||
| 15:00 | FK Borec | - | Akademija Pandev | 1:1 (0:1) | ||
| 15:00 | GFK Tikvesh | - | FC Struga | 2:0 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 26 | 19 | 5 | 2 | 55:15 | 40 | 62 |
| 2 |
|
KF Shkëndija 79 | 26 | 14 | 9 | 3 | 41:18 | 23 | 51 |
| 3 |
|
Akademija Pandev | 26 | 14 | 7 | 5 | 44:24 | 20 | 49 |
| 4 |
|
Makedonija GP | 26 | 15 | 4 | 7 | 39:34 | 5 | 49 |
| 5 |
|
FK Renova | 26 | 9 | 10 | 7 | 32:23 | 9 | 37 |
| 6 |
|
FK Bregalnica Štip | 26 | 10 | 7 | 9 | 37:38 | -1 | 37 |
| 7 |
|
FK Rabotnički | 26 | 10 | 4 | 12 | 23:28 | -5 | 34 |
| 8 |
|
FC Struga | 26 | 8 | 9 | 9 | 22:28 | -6 | 33 |
| 9 |
|
FK Skopje | 26 | 6 | 8 | 12 | 17:36 | -19 | 26 |
| 10 |
|
GFK Tikvesh | 26 | 6 | 6 | 14 | 26:32 | -6 | 24 |
| 11 |
|
FK Borec | 26 | 3 | 6 | 17 | 18:49 | -31 | 15 |
| 12 |
|
FK Pelister | 26 | 1 | 7 | 18 | 10:39 | -29 | 10 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
