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| 02.04.2022 | 15:00 | Toulouse FC | - | Paris FC | 2:1 (0:1) | |
| 19:00 | Dijon FCO | - | Grenoble Foot 38 | 1:0 (0:0) | ||
| 19:00 | Pau FC | - | Havre AC | 2:1 (1:1) | ||
| 19:00 | Valenciennes FC | - | Amiens SC | 0:2 (0:2) | ||
| 19:00 | Nîmes Olympique | - | EA Guingamp | 0:2 (0:0) | ||
| 19:00 | Rodez AF | - | Chamois Niortais | 1:1 (1:1) | ||
| 19:00 | SC Bastia | - | AJ Auxerre | 1:1 (1:0) | ||
| 19:00 | SM Caen | - | USL Dunkerque | 2:1 (1:0) | ||
| 19:00 | US Quevilly-Rouen | - | FC Sochaux | 0:2 (0:1) | ||
| 04.04.2022 | 20:45 | AS Nancy Lorraine | - | AC Ajaccio | 0:2 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Toulouse FC | 31 | 19 | 9 | 3 | 71:27 | 44 | 66 |
| 2 |
|
AC Ajaccio | 31 | 17 | 7 | 7 | 28:15 | 13 | 58 |
| 3 |
|
Paris FC | 31 | 16 | 8 | 7 | 44:29 | 15 | 56 |
| 4 |
|
AJ Auxerre | 31 | 15 | 10 | 6 | 48:34 | 14 | 55 |
| 5 |
|
FC Sochaux | 31 | 15 | 9 | 7 | 37:28 | 9 | 54 |
| 6 |
|
SM Caen | 31 | 11 | 9 | 11 | 44:35 | 9 | 42 |
| 7 |
|
EA Guingamp | 31 | 10 | 12 | 9 | 35:37 | -2 | 42 |
| 8 |
|
Pau FC | 31 | 12 | 6 | 13 | 32:34 | -2 | 42 |
| 9 |
|
Dijon FCO | 31 | 12 | 5 | 14 | 35:37 | -2 | 41 |
| 10 |
|
Havre AC | 31 | 10 | 11 | 10 | 30:33 | -3 | 41 |
| 11 |
|
Amiens SC | 31 | 9 | 13 | 9 | 39:33 | 6 | 40 |
| 12 |
|
Chamois Niortais | 31 | 11 | 7 | 13 | 32:32 | 0 | 40 |
| 13 |
|
Nîmes Olympique | 31 | 11 | 6 | 14 | 35:41 | -6 | 39 |
| 14 |
|
SC Bastia | 31 | 8 | 14 | 9 | 31:29 | 2 | 38 |
| 15 |
|
Valenciennes FC | 31 | 8 | 12 | 11 | 30:40 | -10 | 36 |
| 16 |
|
Rodez AF | 31 | 7 | 12 | 12 | 25:35 | -10 | 33 |
| 17 |
|
Grenoble Foot 38 | 31 | 9 | 6 | 16 | 23:38 | -15 | 33 |
| 18 |
|
US Quevilly-Rouen | 31 | 7 | 10 | 14 | 24:42 | -18 | 31 |
| 19 |
|
USL Dunkerque | 31 | 8 | 6 | 17 | 24:39 | -15 | 30 |
| 20 |
|
AS Nancy Lorraine | 31 | 5 | 8 | 18 | 25:54 | -29 | 23 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
