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| 16.04.2022 | 00:00 | Real Tomayapo | - | Universitario de Vinto | 0:1 (0:1) | |
| 02:00 | Universitario de Sucre | - | Real Santa Cruz | 2:3 (0:1) | ||
| 21:00 | Always Ready | - | Independiente Petrolero | 1:1 (0:1) | ||
| 23:15 | Bolívar | - | Blooming | 6:0 (2:0) | ||
| 17.04.2022 | 01:30 | Jorge Wilstermann | - | Royal Pari | 2:2 (2:1) | |
| 21:00 | Atlético Palmaflor | - | Nacional Potosí | 1:0 (1:0) | ||
| 23:15 | CD Guabirá | - | Club Aurora | 3:2 (2:1) | ||
| 18.04.2022 | 01:30 | Oriente Petrolero | - | The Strongest | 1:1 (1:1) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Palmaflor | 9 | 6 | 1 | 2 | 10:9 | 1 | 19 |
| 2 |
|
The Strongest | 9 | 4 | 3 | 2 | 13:7 | 6 | 15 |
| 3 |
|
Nacional Potosí | 9 | 4 | 2 | 3 | 18:13 | 5 | 14 |
| 4 |
|
Universitario de Sucre | 9 | 4 | 2 | 3 | 14:11 | 3 | 14 |
| 5 |
|
Oriente Petrolero | 9 | 4 | 1 | 4 | 13:12 | 1 | 13 |
| 6 |
|
Club Aurora | 9 | 2 | 3 | 4 | 9:12 | -3 | 9 |
| 7 |
|
Real Santa Cruz | 9 | 2 | 2 | 5 | 11:14 | -3 | 8 |
| 8 |
|
CD Guabirá | 9 | 1 | 2 | 6 | 8:18 | -10 | 5 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 9 | 6 | 1 | 2 | 26:3 | 23 | 19 |
| 2 |
|
Blooming | 9 | 6 | 1 | 2 | 15:18 | -3 | 19 |
| 3 |
|
Always Ready | 9 | 3 | 3 | 3 | 12:11 | 1 | 12 |
| 4 |
|
Royal Pari | 9 | 3 | 3 | 3 | 15:16 | -1 | 12 |
| 5 |
|
Real Tomayapo | 9 | 3 | 3 | 3 | 8:12 | -4 | 12 |
| 6 |
|
Jorge Wilstermann | 9 | 3 | 2 | 4 | 7:8 | -1 | 11 |
| 7 |
|
Independiente Petrolero | 9 | 2 | 3 | 4 | 11:16 | -5 | 9 |
| 8 |
|
Universitario de Vinto | 9 | 2 | 2 | 5 | 9:19 | -10 | 8 |
| Playoffs | |
| Playoffs |
