 |
 |
|
|
| 15.10.2021 | 16:00 | Shakhtar Donetsk | - | Zorya Lugansk | 6:1 (3:0) | |
| 16.10.2021 | 13:00 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 (1:0) | |
| 16:00 | FK Lviv | - | Dinamo Kiev | 1:4 (1:2) | ||
| 18:30 | SK Dnipro-1 | - | Kolos Kovalivka | 2:0 (2:0) | ||
| 17.10.2021 | 13:00 | FC Mynai | - | Desna Chernigov | 0:0 (0:0) | |
| 18:30 | FK Oleksandriya | - | Vorskla Poltava | 1:2 (0:2) | ||
| 18.10.2021 | 18:30 | Chernomorets Odessa | - | NK Veres | 0:1 (0:1) | |
| 16.12.2021 | Inhulets Petrove | - | Rukh Lviv | n.gesp. |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 11 | 9 | 2 | 0 | 29:3 | 26 | 29 |
| 2 |
|
Shakhtar Donetsk | 11 | 8 | 2 | 1 | 29:6 | 23 | 26 |
| 3 |
|
Vorskla Poltava | 11 | 7 | 3 | 1 | 21:8 | 13 | 24 |
| 4 |
|
SK Dnipro-1 | 11 | 7 | 1 | 3 | 16:12 | 4 | 22 |
| 5 |
|
Zorya Lugansk | 11 | 6 | 2 | 3 | 23:15 | 8 | 20 |
| 6 |
|
FK Oleksandriya | 11 | 5 | 3 | 3 | 11:9 | 2 | 18 |
| 7 |
|
Desna Chernigov | 11 | 5 | 2 | 4 | 13:16 | -3 | 17 |
| 8 |
|
Metalist 1925 Kharkiv | 11 | 5 | 1 | 5 | 11:14 | -3 | 16 |
| 9 |
|
NK Veres | 11 | 4 | 3 | 4 | 10:12 | -2 | 15 |
| 10 |
|
Kolos Kovalivka | 11 | 3 | 3 | 5 | 8:17 | -9 | 12 |
| 11 |
|
Rukh Lviv | 10 | 3 | 2 | 5 | 8:12 | -4 | 11 |
| 12 |
|
FC Mynai | 11 | 1 | 5 | 5 | 7:13 | -6 | 8 |
| 13 |
|
Inhulets Petrove | 10 | 2 | 2 | 6 | 9:18 | -9 | 8 |
| 14 |
|
FK Lviv | 11 | 1 | 3 | 7 | 7:19 | -12 | 6 |
| 15 |
|
Chernomorets Odessa | 11 | 1 | 3 | 7 | 11:25 | -14 | 6 |
| 16 |
|
FK Mariupol | 11 | 1 | 1 | 9 | 13:27 | -14 | 4 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
|
# Olimpik Donetsk zog sich vor Beginn der Saison aus allen Wettbewerben zurück. Der Verein wurde aufgelöst. |
