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| 25.02.2022 | 14:00 | FK Radnički 1923 | - | FK Voždovac | 1:0 (1:0) | |
| 16:00 | Mladost Lučani | - | Proleter Novi Sad | 2:1 (1:0) | ||
| 16:00 | Radnički Niš | - | FK Novi Pazar | 1:1 (1:0) | ||
| 18:00 | Spartak Subotica | - | FK Čukarički | 1:2 (1:1) | ||
| 26.02.2022 | 14:00 | FK Napredak | - | TSC Bačka Topola | 2:2 (1:0) | |
| 16:00 | Vojvodina | - | Radnik Surdulica | 0:1 (0:0) | ||
| 18:00 | FK Kolubara | - | FK Metalac | 0:1 (0:0) | ||
| 27.02.2022 | 18:00 | Crvena Zvezda | - | Partizan | 2:0 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 24 | 21 | 2 | 1 | 61:8 | 53 | 65 |
| 2 |
|
Crvena Zvezda | 24 | 20 | 3 | 1 | 57:14 | 43 | 63 |
| 3 |
|
FK Čukarički | 24 | 12 | 8 | 4 | 41:24 | 17 | 44 |
| 4 |
|
Vojvodina | 24 | 10 | 6 | 8 | 33:31 | 2 | 36 |
| 5 |
|
Radnički Niš | 24 | 7 | 11 | 6 | 28:25 | 3 | 32 |
| 6 |
|
FK Napredak | 24 | 9 | 5 | 10 | 28:28 | 0 | 32 |
| 7 |
|
TSC Bačka Topola | 24 | 8 | 6 | 10 | 38:36 | 2 | 30 |
| 8 |
|
FK Voždovac | 24 | 8 | 6 | 10 | 28:28 | 0 | 30 |
| 9 |
|
Mladost Lučani | 24 | 9 | 3 | 12 | 28:33 | -5 | 30 |
| 10 |
|
FK Kolubara | 24 | 9 | 2 | 13 | 26:46 | -20 | 29 |
| 11 |
|
Radnik Surdulica | 24 | 6 | 10 | 8 | 19:25 | -6 | 28 |
| 12 |
|
Spartak Subotica | 24 | 7 | 6 | 11 | 26:40 | -14 | 27 |
| 13 |
|
Proleter Novi Sad | 24 | 8 | 3 | 13 | 19:38 | -19 | 27 |
| 14 |
|
FK Metalac | 24 | 6 | 4 | 14 | 29:44 | -15 | 22 |
| 15 |
|
FK Radnički 1923 | 24 | 5 | 4 | 15 | 21:44 | -23 | 19 |
| 16 |
|
FK Novi Pazar | 24 | 3 | 9 | 12 | 22:40 | -18 | 18 |
| Playoffs | |
| Relegation |
