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| 08.05.2021 | 14:00 | TSV Steinbach Haiger | - | Eintracht Stadtallendorf | 2:1 (1:0) | |
| 14:00 | FC 08 Homburg | - | 1899 Hoffenheim II | 1:1 (0:0) | ||
| 14:00 | FC-Astoria Walldorf | - | 1. FSV Mainz 05 II | 4:2 (2:1) | ||
| 14:00 | FC Gießen | - | SSV Ulm 1846 | 1:2 (0:0) | ||
| 14:00 | FK Pirmasens | - | VfR Aalen | 2:0 (2:0) | ||
| 14:00 | FSV Frankfurt | - | Bahlinger SC | 4:2 (1:2) | ||
| 14:00 | Hessen Kassel | - | TSG Balingen | 2:2 (2:0) | ||
| 14:00 | Rot-Weiß Koblenz | - | SG Sonnenhof Großaspach | 3:0 (1:0) | ||
| 14:00 | SV 07 Elversberg | - | Kickers Offenbach | 3:0 (1:0) | ||
| 14:00 | TSV Schott Mainz | - | SC Freiburg II | 0:2 (0:1) | ||
| 14:00 | VfB Stuttgart II | - | Bayern Alzenau | 3:2 (1:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 37 | 26 | 7 | 4 | 87:35 | 52 | 85 |
| 2 |
|
SV 07 Elversberg | 37 | 21 | 12 | 4 | 89:40 | 49 | 75 |
| 3 |
|
Kickers Offenbach | 37 | 21 | 11 | 5 | 67:29 | 38 | 74 |
| 4 |
|
TSV Steinbach Haiger | 37 | 21 | 9 | 7 | 77:35 | 42 | 72 |
| 5 |
|
SSV Ulm 1846 | 37 | 21 | 9 | 7 | 67:32 | 35 | 72 |
| 6 |
|
FSV Frankfurt | 37 | 19 | 8 | 10 | 53:42 | 11 | 65 |
| 7 |
|
FC 08 Homburg | 37 | 14 | 14 | 9 | 64:51 | 13 | 56 |
| 8 |
|
VfB Stuttgart II | 37 | 16 | 7 | 14 | 67:48 | 19 | 55 |
| 9 |
|
Bahlinger SC | 37 | 15 | 8 | 14 | 58:68 | -10 | 53 |
| 10 |
|
Rot-Weiß Koblenz | 37 | 14 | 10 | 13 | 49:49 | 0 | 52 |
| 11 |
|
VfR Aalen | 37 | 12 | 12 | 13 | 41:49 | -8 | 48 |
| 12 |
|
1. FSV Mainz 05 II | 37 | 12 | 10 | 15 | 54:66 | -12 | 46 |
| 13 |
|
Hessen Kassel | 37 | 11 | 12 | 14 | 51:66 | -15 | 45 |
| 14 |
|
1899 Hoffenheim II | 37 | 11 | 10 | 16 | 50:65 | -15 | 43 |
| 15 |
|
FK Pirmasens | 37 | 10 | 13 | 14 | 36:54 | -18 | 43 |
| 16 |
|
TSG Balingen | 37 | 11 | 9 | 17 | 45:57 | -12 | 42 |
| 17 |
|
FC Gießen | 37 | 9 | 13 | 15 | 39:48 | -9 | 40 |
| 18 |
|
FC-Astoria Walldorf | 37 | 12 | 4 | 21 | 55:66 | -11 | 40 |
| 19 |
|
SG Sonnenhof Großaspach | 37 | 9 | 10 | 18 | 46:66 | -20 | 37 |
| 20 |
|
TSV Schott Mainz | 37 | 10 | 5 | 22 | 49:89 | -40 | 35 |
| 21 |
|
Bayern Alzenau | 37 | 5 | 9 | 23 | 44:81 | -37 | 24 |
| 22 |
|
Eintracht Stadtallendorf | 37 | 3 | 6 | 28 | 32:84 | -52 | 15 |
| Aufstieg | |
| Abstieg |
