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| 12.04.1981 | STV Horst-Emscher | - | Hammer SpVg | 0:2 | ||
| Teutonia Lippstadt | - | SV Holzwickede | 2:1 | |||
| Hellweg Lütgendortmund | - | TuS Schloß-Neuhaus | 0:3 | |||
| Bünder SV | - | SuS Hüsten 09 | 0:4 | |||
| VfL Gevelsberg | - | VfB Waltrop | 0:0 | |||
| FC Gütersloh | - | Eintracht Recklinghausen | 2:0 | |||
| Westfalia Herne | - | DSC Wanne-Eickel | 0:2 | |||
| VfB Rheine | - | Sportfreunde Siegen | 3:0 | |||
| 1. FC Paderborn | - | VfB Altena | 1:0 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfL Gevelsberg | 30 | 16 | 10 | 4 | 60:33 | 27 | 42:18 |
| 2 |
|
1. FC Paderborn | 30 | 18 | 4 | 8 | 55:34 | 21 | 40:20 |
| 3 |
|
VfB Rheine | 30 | 16 | 7 | 7 | 63:37 | 26 | 39:21 |
| 4 |
|
FC Gütersloh | 30 | 16 | 6 | 8 | 55:37 | 18 | 38:22 |
| 5 |
|
Hammer SpVg | 30 | 15 | 7 | 8 | 59:43 | 16 | 37:23 |
| 6 |
|
DSC Wanne-Eickel | 30 | 13 | 10 | 7 | 69:43 | 26 | 36:24 |
| 7 |
|
TuS Schloß-Neuhaus | 30 | 15 | 6 | 9 | 56:41 | 15 | 36:24 |
| 8 |
|
Sportfreunde Siegen | 30 | 13 | 8 | 9 | 49:43 | 6 | 34:26 |
| 9 |
|
VfB Waltrop | 30 | 11 | 9 | 10 | 46:45 | 1 | 31:29 |
| 10 |
|
Westfalia Herne | 30 | 8 | 13 | 9 | 41:46 | -5 | 29:31 |
| 11 |
|
SuS Hüsten 09 | 30 | 9 | 10 | 11 | 40:42 | -2 | 28:32 |
| 12 |
|
Teutonia Lippstadt | 30 | 9 | 8 | 13 | 49:45 | 4 | 26:34 |
| 13 |
|
Hellweg Lütgendortmund | 30 | 8 | 10 | 12 | 36:49 | -13 | 26:34 |
| 14 |
|
Eintracht Recklinghausen | 30 | 6 | 9 | 15 | 39:63 | -24 | 21:39 |
| 15 |
|
STV Horst-Emscher | 30 | 7 | 7 | 16 | 34:70 | -36 | 21:39 |
| 16 |
|
SV Holzwickede | 30 | 5 | 9 | 16 | 34:52 | -18 | 19:41 |
| 17 |
|
VfB Altena | 30 | 5 | 9 | 16 | 32:66 | -34 | 19:41 |
| 18 |
|
Bünder SV | 30 | 6 | 6 | 18 | 35:63 | -28 | 18:42 |
