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| 10.10.2021 | 15:00 | 1. FC Monheim | - | SC Union Nettetal | 2:1 (1:0) | |
| 15:00 | Germania Ratingen 04/19 | - | SC Düsseldorf-West | 2:2 (0:1) | ||
| 15:00 | FC Kray | - | TSV Meerbusch | 0:4 (0:2) | ||
| 15:00 | SC Velbert | - | Sportfreunde Niederwenigern | 1:2 (0:1) | ||
| 15:00 | Schwarz-Weiß Essen | - | 1. FC Bocholt | 0:3 (0:3) | ||
| 15:15 | SpVgg Sterkrade-Nord | - | SSVg Velbert | 0:2 (0:2) | ||
| 15:30 | VfB 03 Hilden | - | TV Jahn Hiesfeld | 1:0 (0:0) | ||
| 15:30 | DJK Teutonia St. Tönis | - | 1. FC Kleve | 1:2 (0:1) | ||
| 15:30 | 1. FC Mönchengladbach | - | Cronenberger SC | 2:1 (0:1) | ||
| 15:30 | TuRU Düsseldorf | - | Sportfreunde Baumberg | 2:0 (1:0) | ||
| 15:30 | FSV Duisburg | - | SpVg Schonnebeck | 1:2 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSVg Velbert | 7 | 5 | 2 | 0 | 16:6 | 10 | 17 |
| 2 |
|
TuRU Düsseldorf | 8 | 5 | 2 | 1 | 16:10 | 6 | 17 |
| 3 |
|
VfB 03 Hilden | 7 | 5 | 1 | 1 | 16:7 | 9 | 16 |
| 4 |
|
1. FC Bocholt | 7 | 4 | 3 | 0 | 27:7 | 20 | 15 |
| 5 |
|
SpVg Schonnebeck | 8 | 4 | 3 | 1 | 21:11 | 10 | 15 |
| 6 |
|
1. FC Kleve | 8 | 4 | 3 | 1 | 13:10 | 3 | 15 |
| 7 |
|
Germania Ratingen 04/19 | 8 | 4 | 2 | 2 | 20:10 | 10 | 14 |
| 8 |
|
1. FC Monheim | 8 | 4 | 2 | 2 | 14:7 | 7 | 14 |
| 9 |
|
TVD Velbert | 7 | 4 | 1 | 2 | 11:9 | 2 | 13 |
| 10 |
|
Sportfreunde Baumberg | 8 | 4 | 0 | 4 | 17:14 | 3 | 12 |
| 11 |
|
Schwarz-Weiß Essen | 8 | 4 | 0 | 4 | 11:15 | -4 | 12 |
| 12 |
|
Sportfreunde Niederwenigern | 8 | 3 | 3 | 2 | 14:19 | -5 | 12 |
| 13 |
|
SC Velbert | 7 | 3 | 2 | 2 | 15:9 | 6 | 11 |
| 14 |
|
TSV Meerbusch | 7 | 3 | 0 | 4 | 13:15 | -2 | 9 |
| 15 |
|
DJK Teutonia St. Tönis | 8 | 2 | 2 | 4 | 13:17 | -4 | 8 |
| 16 |
|
SC Düsseldorf-West | 8 | 2 | 2 | 4 | 11:17 | -6 | 8 |
| 17 |
|
FC Kray | 8 | 2 | 2 | 4 | 15:22 | -7 | 8 |
| 18 |
|
1. FC Mönchengladbach | 7 | 2 | 1 | 4 | 10:23 | -13 | 7 |
| 19 |
|
SC Union Nettetal | 8 | 2 | 0 | 6 | 11:16 | -5 | 6 |
| 20 |
|
TV Jahn Hiesfeld | 8 | 1 | 2 | 5 | 11:13 | -2 | 5 |
| 21 |
|
FSV Duisburg | 7 | 1 | 2 | 4 | 9:12 | -3 | 5 |
| 22 |
|
Cronenberger SC | 8 | 1 | 2 | 5 | 8:23 | -15 | 5 |
| 23 |
|
SpVgg Sterkrade-Nord | 8 | 0 | 1 | 7 | 7:27 | -20 | 1 |
| Playoffs | |
| Playoffs |
