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| H | CF Pachuca | - | Deportivo Guadalajara | 3:3 (2:2) | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 1:3 (0:1) | ||
| H: 19.05.2023 02:00 | R: 22.05.2023 01:00 | Sieger: CF Pachuca | ||||
| H | Atlas Guadalajara | - | UANL Tigres | 0:5 (0:3) | ||
| R | UANL Tigres | - | Atlas Guadalajara | 2:0 (0:0) | ||
| H: 20.05.2023 02:00 | R: 23.05.2023 03:00 | Sieger: UANL Tigres | ||||
| H | FC Juárez | - | CF América | 1:3 (0:2) | ||
| R | CF América | - | FC Juárez | 5:1 (2:0) | ||
| H: 20.05.2023 04:00 | R: 23.05.2023 01:00 | Sieger: CF América | ||||
| H | Club Tijuana | - | CF Monterrey | 2:0 (2:0) | ||
| R | CF Monterrey | - | Club Tijuana | 6:1 (1:1) | ||
| H: 20.05.2023 06:00 | R: 23.05.2023 05:00 | Sieger: CF Monterrey | ||||
