 |
 |
|
|
| 26.03.2022 | 19:00 | Cruz Azul | - | Atlas Guadalajara | 2:1 (2:0) | |
| 27.03.2022 | 03:00 | FC Juárez | - | Pumas UNAM | 1:0 (0:0) | |
| 18:00 | CF Monterrey | - | Santos Laguna | 3:1 (2:0) | ||
| 20:00 | Puebla FC | - | CF América | 1:1 (1:0) | ||
| 28.03.2022 | 01:00 | Atlético San Luis | - | UANL Tigres | 0:6 (0:3) | |
| 29.03.2022 | 01:00 | Deportivo Toluca | - | Gallos Blancos | 3:0 (0:0) | |
| 03:00 | CF Pachuca | - | Mazatlán FC | 5:0 (1:0) | ||
| 05:00 | Club León | - | Deportivo Guadalajara | 0:2 (0:1) | ||
| 05:00 | Club Tijuana | - | Club Necaxa | 1:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 13 | 12 | 0 | 1 | 43:11 | 32 | 36 |
| 2 |
|
UANL Tigres | 13 | 9 | 4 | 0 | 37:9 | 28 | 31 |
| 3 |
|
Deportivo Guadalajara | 13 | 9 | 4 | 0 | 22:5 | 17 | 31 |
| 4 |
|
CF América | 13 | 9 | 2 | 2 | 32:10 | 22 | 29 |
| 5 |
|
CF Pachuca | 13 | 9 | 1 | 3 | 25:10 | 15 | 28 |
| 6 |
|
Atlas Guadalajara | 13 | 5 | 5 | 3 | 20:19 | 1 | 20 |
| 7 |
|
Pumas UNAM | 13 | 4 | 4 | 5 | 12:11 | 1 | 16 |
| 8 |
|
Deportivo Toluca | 13 | 4 | 4 | 5 | 21:24 | -3 | 16 |
| 9 |
|
Gallos Blancos | 13 | 4 | 3 | 6 | 13:22 | -9 | 15 |
| 10 |
|
Club Tijuana | 13 | 2 | 8 | 3 | 16:23 | -7 | 14 |
| 11 |
|
Cruz Azul | 13 | 3 | 3 | 7 | 13:23 | -10 | 12 |
| 12 |
|
Club León | 13 | 3 | 3 | 7 | 13:29 | -16 | 12 |
| 13 |
|
Puebla FC | 13 | 3 | 2 | 8 | 10:20 | -10 | 11 |
| 14 |
|
Atlético San Luis | 13 | 2 | 5 | 6 | 13:25 | -12 | 11 |
| 15 |
|
Club Necaxa | 13 | 2 | 5 | 6 | 13:26 | -13 | 11 |
| 16 |
|
Santos Laguna | 13 | 3 | 1 | 9 | 12:24 | -12 | 10 |
| 17 |
|
Mazatlán FC | 13 | 2 | 4 | 7 | 9:25 | -16 | 10 |
| 18 |
|
FC Juárez | 13 | 2 | 2 | 9 | 12:20 | -8 | 8 |
| Playoffs |
