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| 29.01.2022 | 16:00 | AE Lárissa | - | PAOK Saloniki II | 0:0 (0:0) | |
| 30.01.2022 | 13:45 | Apollon Lárissa | - | Olympiakos Volou | 1:1 (1:0) | |
| 13:45 | Olympiakos Piraeus II | - | Niki Volou FC | 2:0 (1:0) | ||
| 13:45 | Panserraikos | - | Almopos Arideas | 1:3 (0:0) | ||
| 13:45 | AEP Iraklis FC | - | AO Kavala | 1:2 (0:1) | ||
| 13:45 | Veria FC | - | Thesprotos | 2:1 (1:0) | ||
| 13:45 | Apollon Pontou | - | Xanthi FC | 0:0 (0:0) | ||
| 13:45 | Anagennisi Karditsa | - | Pierikos Katerini | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 15 | 10 | 3 | 2 | 35:14 | 21 | 33 |
| 2 |
|
Anagennisi Karditsa | 15 | 9 | 3 | 3 | 27:12 | 15 | 30 |
| 3 |
|
AE Lárissa | 15 | 8 | 6 | 1 | 20:5 | 15 | 30 |
| 4 |
|
Xanthi FC | 15 | 7 | 5 | 3 | 20:10 | 10 | 26 |
| 5 |
|
Olympiakos Piraeus II | 15 | 5 | 7 | 3 | 17:15 | 2 | 22 |
| 6 |
|
Almopos Arideas | 15 | 6 | 3 | 6 | 21:15 | 6 | 21 |
| 7 |
|
AEP Iraklis FC | 15 | 4 | 9 | 2 | 15:11 | 4 | 21 |
| 8 |
|
Niki Volou FC | 15 | 5 | 5 | 5 | 19:12 | 7 | 20 |
| 9 |
|
PAOK Saloniki II | 15 | 4 | 7 | 4 | 18:16 | 2 | 19 |
| 10 |
|
Thesprotos | 15 | 5 | 3 | 7 | 20:18 | 2 | 18 |
| 11 |
|
Olympiakos Volou | 15 | 4 | 4 | 7 | 19:23 | -4 | 16 |
| 12 |
|
AO Trikala | 15 | 4 | 4 | 7 | 13:24 | -11 | 16 |
| 13 |
|
Pierikos Katerini | 16 | 3 | 6 | 7 | 16:20 | -4 | 15 |
| 14 |
|
Apollon Pontou | 15 | 3 | 5 | 7 | 18:23 | -5 | 14 |
| 15 |
|
Panserraikos | 15 | 2 | 7 | 6 | 16:24 | -8 | 13 |
| 16 |
|
Apollon Lárissa | 15 | 2 | 7 | 6 | 12:20 | -8 | 13 |
| 17 |
|
AO Kavala | 15 | 3 | 4 | 8 | 11:55 | -44 | 13 |
| Playoffs | |
| Abstieg |
|
# Apollon Lárissa wurde mit einem Abzug von 6 Punkten belegt. |
