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| 29.04.2022 | 19:00 | FC Bastia-Borgo | - | US Créteil-Lusitanos | 2:0 (1:0) | |
| 19:00 | FC Annecy | - | FC Sète | 3:0 (2:0) | ||
| 19:00 | Red Star FC | - | CS Sedan | 0:1 (0:0) | ||
| 19:00 | FC Villefranche Beaujolais | - | LB Châteauroux | 2:1 (0:0) | ||
| 19:00 | SO Cholet | - | Le Mans FC | 1:0 (1:0) | ||
| 19:00 | US Avranches | - | Stade Briochin | 2:5 (1:4) | ||
| 19:00 | US Boulogne | - | US Concarneau | 1:0 (1:0) | ||
| 19:00 | US Orléans | - | FC Bourg-Péronnas | 0:0 (0:0) | ||
| 02.05.2022 | 18:45 | FC Chambly | - | Stade Lavallois | 0:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stade Lavallois | 32 | 20 | 6 | 6 | 46:26 | 20 | 66 |
| 2 |
|
FC Annecy | 32 | 18 | 9 | 5 | 53:27 | 26 | 63 |
| 3 |
|
FC Villefranche Beaujolais | 32 | 17 | 8 | 7 | 42:28 | 14 | 59 |
| 4 |
|
US Concarneau | 32 | 14 | 13 | 5 | 43:26 | 17 | 55 |
| 5 |
|
FC Bourg-Péronnas | 32 | 14 | 9 | 9 | 51:33 | 18 | 51 |
| 6 |
|
LB Châteauroux | 32 | 14 | 9 | 9 | 40:28 | 12 | 51 |
| 7 |
|
Stade Briochin | 32 | 13 | 9 | 10 | 44:33 | 11 | 48 |
| 8 |
|
CS Sedan | 32 | 12 | 11 | 9 | 36:35 | 1 | 47 |
| 9 |
|
Le Mans FC | 32 | 12 | 9 | 11 | 32:30 | 2 | 45 |
| 10 |
|
US Orléans | 32 | 11 | 11 | 10 | 34:32 | 2 | 44 |
| 11 |
|
Red Star FC | 32 | 12 | 5 | 15 | 48:47 | 1 | 40 |
| 12 |
|
SO Cholet | 32 | 11 | 7 | 14 | 45:57 | -12 | 40 |
| 13 |
|
US Avranches | 32 | 10 | 6 | 16 | 32:56 | -24 | 36 |
| 14 |
|
FC Sète | 32 | 9 | 7 | 16 | 33:40 | -7 | 34 |
| 15 |
|
FC Bastia-Borgo | 32 | 7 | 9 | 16 | 39:56 | -17 | 30 |
| 16 |
|
FC Chambly | 32 | 6 | 8 | 18 | 34:58 | -24 | 26 |
| 17 |
|
US Boulogne | 32 | 6 | 9 | 17 | 28:46 | -18 | 26 |
| 18 |
|
US Créteil-Lusitanos | 32 | 6 | 7 | 19 | 30:52 | -22 | 25 |
| Aufstieg | |
| Relegation | |
| Abstieg |
