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| 04.02.2022 | 19:00 | FC Bourg-Péronnas | - | US Avranches | 2:0 (2:0) | |
| 19:00 | CS Sedan | - | SO Cholet | 3:1 (2:0) | ||
| 19:00 | FC Chambly | - | US Orléans | 2:2 (0:0) | ||
| 19:00 | Red Star FC | - | Stade Briochin | 1:1 (0:1) | ||
| 19:00 | FC Sète | - | Le Mans FC | 0:0 (0:0) | ||
| 19:00 | LB Châteauroux | - | US Créteil-Lusitanos | 4:1 (3:1) | ||
| 19:00 | Stade Lavallois | - | FC Bastia-Borgo | 1:0 (1:0) | ||
| 19:00 | US Boulogne | - | FC Annecy | 1:1 (0:1) | ||
| 07.02.2022 | 20:45 | US Concarneau | - | FC Villefranche Beaujolais | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Concarneau | 20 | 12 | 5 | 3 | 28:13 | 15 | 41 |
| 2 |
|
Stade Lavallois | 20 | 13 | 2 | 5 | 25:16 | 9 | 41 |
| 3 |
|
FC Annecy | 20 | 10 | 7 | 3 | 28:12 | 16 | 37 |
| 4 |
|
FC Bourg-Péronnas | 20 | 10 | 5 | 5 | 36:19 | 17 | 35 |
| 5 |
|
LB Châteauroux | 20 | 9 | 6 | 5 | 26:17 | 9 | 33 |
| 6 |
|
FC Villefranche Beaujolais | 20 | 9 | 6 | 5 | 22:16 | 6 | 33 |
| 7 |
|
Le Mans FC | 20 | 9 | 6 | 5 | 21:16 | 5 | 33 |
| 8 |
|
SO Cholet | 20 | 9 | 3 | 8 | 33:36 | -3 | 30 |
| 9 |
|
CS Sedan | 20 | 7 | 8 | 5 | 23:21 | 2 | 29 |
| 10 |
|
US Orléans | 20 | 7 | 6 | 7 | 24:23 | 1 | 27 |
| 11 |
|
FC Sète | 20 | 7 | 3 | 10 | 23:24 | -1 | 24 |
| 12 |
|
US Avranches | 20 | 7 | 3 | 10 | 20:34 | -14 | 24 |
| 13 |
|
Red Star FC | 20 | 7 | 2 | 11 | 31:33 | -2 | 22 |
| 14 |
|
Stade Briochin | 20 | 5 | 7 | 8 | 17:20 | -3 | 22 |
| 15 |
|
FC Chambly | 20 | 5 | 5 | 10 | 25:34 | -9 | 20 |
| 16 |
|
US Créteil-Lusitanos | 20 | 4 | 4 | 12 | 18:34 | -16 | 16 |
| 17 |
|
FC Bastia-Borgo | 20 | 3 | 6 | 11 | 20:36 | -16 | 15 |
| 18 |
|
US Boulogne | 20 | 2 | 6 | 12 | 17:33 | -16 | 11 |
| Aufstieg | |
| Relegation | |
| Abstieg |
