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| H | Santiago Morning | - | Deportes Temuco | 1:1 (0:0) | ||
| R | Deportes Temuco | - | Santiago Morning | 2:1 (1:0) | ||
| H: 25.11.2021 22:00 | R: 02.12.2021 00:30 | Sieger: Deportes Temuco | ||||
| H | Puerto Montt | - | Copiapó | 0:1 (0:0) | ||
| R | Copiapó | - | Puerto Montt | 2:2 (2:0) | ||
| H: 26.11.2021 00:30 | R: 01.12.2021 21:45 | Sieger: Copiapó | ||||
