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| 17.09.2021 | 18:30 | SV Seligenporten | - | SpVgg Ansbach | 0:3 (0:1) | |
| 18.09.2021 | 14:00 | Eintracht Bamberg | - | Vatan Spor Aschaffenburg | 2:0 (0:0) | |
| 14:30 | ASV Neumarkt | - | DJK Vilzing | 1:3 (1:2) | ||
| 15:00 | SpVgg Bayern Hof | - | DJK Gebenbach | 3:1 (2:1) | ||
| 16:00 | 1. FC Sand | - | ATSV Erlangen | 0:2 (0:1) | ||
| 16:00 | TSV Abtswind | - | Würzburger FV | 3:0 (1:0) | ||
| 17:00 | TSV Großbardorf | - | ASV Cham | 5:1 (4:0) | ||
| 19.09.2021 | 15:00 | DJK Bamberg | - | DJK Ammerthal | 4:1 (1:1) | |
| 17:00 | TSV Karlburg | - | 1. SC Feucht | 0:2 (0:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Eintracht Bamberg | 12 | 10 | 1 | 1 | 38:8 | 30 | 31 |
| 2 |
|
SpVgg Ansbach | 12 | 9 | 1 | 2 | 29:8 | 21 | 28 |
| 3 |
|
DJK Vilzing | 12 | 9 | 0 | 3 | 28:12 | 16 | 27 |
| 4 |
|
ASV Neumarkt | 12 | 8 | 1 | 3 | 28:16 | 12 | 25 |
| 5 |
|
DJK Ammerthal | 12 | 7 | 2 | 3 | 31:19 | 12 | 23 |
| 6 |
|
ATSV Erlangen | 12 | 7 | 2 | 3 | 18:15 | 3 | 23 |
| 7 |
|
1. SC Feucht | 12 | 6 | 3 | 3 | 21:14 | 7 | 21 |
| 8 |
|
TSV Abtswind | 12 | 6 | 2 | 4 | 18:13 | 5 | 20 |
| 9 |
|
SpVgg Bayern Hof | 12 | 5 | 2 | 5 | 29:27 | 2 | 17 |
| 10 |
|
DJK Bamberg | 12 | 5 | 1 | 6 | 18:18 | 0 | 16 |
| 11 |
|
TSV Großbardorf | 12 | 5 | 1 | 6 | 20:23 | -3 | 16 |
| 12 |
|
DJK Gebenbach | 12 | 4 | 1 | 7 | 23:30 | -7 | 13 |
| 13 |
|
1. FC Sand | 12 | 3 | 3 | 6 | 13:23 | -10 | 12 |
| 14 |
|
TSV Karlburg | 12 | 2 | 5 | 5 | 10:20 | -10 | 11 |
| 15 |
|
ASV Cham | 12 | 2 | 2 | 8 | 15:32 | -17 | 8 |
| 16 |
|
Vatan Spor Aschaffenburg | 12 | 2 | 1 | 9 | 10:29 | -19 | 7 |
| 17 |
|
Würzburger FV | 12 | 2 | 1 | 9 | 12:32 | -20 | 7 |
| 18 |
|
SV Seligenporten | 12 | 1 | 1 | 10 | 12:34 | -22 | 4 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
