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| 16.05.2021 | 15:30 | SV Darmstadt 98 | - | 1. FC Heidenheim 1846 | 5:1 (2:1) | |
| 15:30 | VfL Osnabrück | - | Hamburger SV | 3:2 (1:1) | ||
| 15:30 | FC St. Pauli | - | Hannover 96 | 1:2 (0:1) | ||
| 15:30 | Fortuna Düsseldorf | - | Erzgebirge Aue | 3:0 (2:0) | ||
| 15:30 | 1. FC Nürnberg | - | VfL Bochum | 1:1 (1:0) | ||
| 15:30 | SC Paderborn 07 | - | SpVgg Greuther Fürth | 2:4 (2:2) | ||
| 15:30 | Karlsruher SC | - | Holstein Kiel | 3:2 (0:1) | ||
| 15:30 | SV Sandhausen | - | Jahn Regensburg | 2:0 (2:0) | ||
| 15:30 | Eintracht Braunschweig | - | Würzburger Kickers | 1:2 (0:2) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfL Bochum | 33 | 20 | 4 | 9 | 63:38 | 25 | 64 |
| 2 |
|
Holstein Kiel | 33 | 18 | 8 | 7 | 55:32 | 23 | 62 |
| 3 |
|
SpVgg Greuther Fürth | 33 | 17 | 10 | 6 | 66:42 | 24 | 61 |
| 4 |
|
Fortuna Düsseldorf | 33 | 16 | 8 | 9 | 53:43 | 10 | 56 |
| 5 |
|
Hamburger SV | 33 | 15 | 10 | 8 | 67:44 | 23 | 55 |
| 6 |
|
1. FC Heidenheim 1846 | 33 | 15 | 6 | 12 | 48:47 | 1 | 51 |
| 7 |
|
Karlsruher SC | 33 | 13 | 10 | 10 | 49:43 | 6 | 49 |
| 8 |
|
SV Darmstadt 98 | 33 | 14 | 6 | 13 | 60:53 | 7 | 48 |
| 9 |
|
FC St. Pauli | 33 | 13 | 8 | 12 | 51:53 | -2 | 47 |
| 10 |
|
SC Paderborn 07 | 33 | 12 | 10 | 11 | 52:44 | 8 | 46 |
| 11 |
|
Hannover 96 | 33 | 12 | 6 | 15 | 52:49 | 3 | 42 |
| 12 |
|
1. FC Nürnberg | 33 | 10 | 11 | 12 | 44:50 | -6 | 41 |
| 13 |
|
Erzgebirge Aue | 33 | 11 | 8 | 14 | 42:52 | -10 | 41 |
| 14 |
|
Jahn Regensburg | 33 | 8 | 11 | 14 | 34:50 | -16 | 35 |
| 15 |
|
SV Sandhausen | 33 | 10 | 4 | 19 | 40:57 | -17 | 34 |
| 16 |
|
VfL Osnabrück | 33 | 9 | 6 | 18 | 34:56 | -22 | 33 |
| 17 |
|
Eintracht Braunschweig | 33 | 7 | 10 | 16 | 30:55 | -25 | 31 |
| 18 |
|
Würzburger Kickers | 33 | 6 | 6 | 21 | 36:68 | -32 | 24 |
| Aufstieg | |
| Relegation | |
| Relegation | |
| Abstieg |
