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| 05.03.2021 | 18:30 | Würzburger Kickers | - | 1. FC Heidenheim 1846 | 1:2 (0:0) | |
| 18:30 | SC Paderborn 07 | - | SV Darmstadt 98 | 2:3 (1:1) | ||
| 06.03.2021 | 13:00 | Erzgebirge Aue | - | Hannover 96 | 1:1 (0:1) | |
| 13:00 | SpVgg Greuther Fürth | - | VfL Bochum | 1:2 (1:1) | ||
| 13:00 | Karlsruher SC | - | FC St. Pauli | 0:0 (0:0) | ||
| 07.03.2021 | 13:30 | Eintracht Braunschweig | - | SV Sandhausen | 1:0 (0:0) | |
| 13:30 | Fortuna Düsseldorf | - | 1. FC Nürnberg | 3:1 (0:0) | ||
| 08.03.2021 | 20:30 | Hamburger SV | - | Holstein Kiel | 1:1 (1:1) | |
| 14.04.2021 | 18:30 | VfL Osnabrück | - | Jahn Regensburg | 0:1 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfL Bochum | 24 | 15 | 3 | 6 | 45:24 | 21 | 48 |
| 2 |
|
Holstein Kiel | 24 | 13 | 7 | 4 | 38:22 | 16 | 46 |
| 3 |
|
Hamburger SV | 24 | 12 | 7 | 5 | 49:30 | 19 | 43 |
| 4 |
|
SpVgg Greuther Fürth | 24 | 12 | 7 | 5 | 46:29 | 17 | 43 |
| 5 |
|
Karlsruher SC | 24 | 12 | 4 | 8 | 37:30 | 7 | 40 |
| 6 |
|
1. FC Heidenheim 1846 | 24 | 11 | 6 | 7 | 37:32 | 5 | 39 |
| 7 |
|
Fortuna Düsseldorf | 24 | 11 | 6 | 7 | 37:33 | 4 | 39 |
| 8 |
|
Hannover 96 | 24 | 10 | 5 | 9 | 36:28 | 8 | 35 |
| 9 |
|
Erzgebirge Aue | 24 | 9 | 6 | 9 | 32:32 | 0 | 33 |
| 10 |
|
FC St. Pauli | 24 | 8 | 8 | 8 | 37:40 | -3 | 32 |
| 11 |
|
Jahn Regensburg | 24 | 8 | 8 | 8 | 26:29 | -3 | 32 |
| 12 |
|
SC Paderborn 07 | 24 | 8 | 7 | 9 | 30:30 | 0 | 31 |
| 13 |
|
SV Darmstadt 98 | 24 | 8 | 4 | 12 | 37:42 | -5 | 28 |
| 14 |
|
1. FC Nürnberg | 24 | 7 | 6 | 11 | 30:37 | -7 | 27 |
| 15 |
|
Eintracht Braunschweig | 24 | 6 | 6 | 12 | 22:43 | -21 | 24 |
| 16 |
|
VfL Osnabrück | 24 | 6 | 4 | 14 | 22:38 | -16 | 22 |
| 17 |
|
SV Sandhausen | 24 | 6 | 3 | 15 | 28:45 | -17 | 21 |
| 18 |
|
Würzburger Kickers | 24 | 4 | 3 | 17 | 26:51 | -25 | 15 |
| Aufstieg | |
| Relegation | |
| Relegation | |
| Abstieg |
