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| 14.01.2023 | 15:00 | Guilsfield FC | - | Holywell Town | 1:2 (0:2) | |
| 15:00 | Gresford Athletic | - | Penybont FC | 0:2 (0:1) | ||
| 15:00 | Briton Ferry Llansawel AFC | - | Buckley Town | 8:7 (2:1, 2:2) i.E. | ||
| 15:00 | The New Saints | - | Newtown AFC | 7:0 (4:0) | ||
| 15:00 | Pontardawe Town | - | Airbus UK | 4:5 (1:1, 1:1) i.E. | ||
| 15:00 | Bala Town | - | Pontypridd United | 2:1 (1:0) | ||
| 18:15 | Llanelli Town | - | Connah's Quay Nomads | 0:2 (0:1) | ||
| 25.01.2023 | 20:30 | Penydarren Boys & Girls | - | Cwmbran Celtic | 2:3 (0:3) |
