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| H | Colorado Rapids | - | Columbus Crew | 1:0 (1:0) | ||
| R | Columbus Crew | - | Colorado Rapids | 4:5 (1:0, 2:1, 2:1) i.E. | ||
| H: 29.10.2010 03:00 | R: 06.11.2010 21:00 | Sieger: Colorado Rapids | ||||
| H | FC Dallas | - | Real Salt Lake | 2:1 (1:1) | ||
| R | Real Salt Lake | - | FC Dallas | 1:1 (0:1) | ||
| H: 30.10.2010 23:00 | R: 07.11.2010 03:00 | Sieger: FC Dallas | ||||
| H | San Jose Earthquakes | - | New York RB | 0:1 (0:0) | ||
| R | New York RB | - | San Jose Earthquakes | 1:3 (0:1) | ||
| H: 31.10.2010 03:00 | R: 05.11.2010 01:00 | Sieger: San Jose Earthquakes | ||||
| H | Seattle Sounders | - | Los Angeles Galaxy | 0:1 (0:1) | ||
| R | Los Angeles Galaxy | - | Seattle Sounders | 2:1 (2:0) | ||
| H: 01.11.2010 01:00 | R: 08.11.2010 03:00 | Sieger: Los Angeles Galaxy | ||||
