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| H | Miramar Misiones | - | CA Cerro | 0:2 (0:2) | ||
| R | CA Cerro | - | Miramar Misiones | 1:3 (1:0) | ||
| H: 01.10.2022 20:00 | R: 08.10.2022 18:30 | Sieger: Miramar Misiones | ||||
| H | Rampla Juniors | - | Uruguay Montevideo | 1:0 (1:0) | ||
| R | Uruguay Montevideo | - | Rampla Juniors | 1:1 (0:1) | ||
| H: 02.10.2022 18:30 | R: 09.10.2022 18:30 | Sieger: Rampla Juniors | ||||
