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| 05.05.2021 | 13:00 | Dinamo Kiev | - | FK Mariupol | 0:0 (0:0) | |
| 18:00 | FK Oleksandriya | - | Kolos Kovalivka | 0:2 (0:1) | ||
| 18:00 | Vorskla Poltava | - | Desna Chernigov | 1:1 (1:0) | ||
| 18:00 | SK Dnipro-1 | - | Zorya Lugansk | 0:1 (0:0) | ||
| 06.05.2021 | 18:00 | Inhulets Petrove | - | FK Lviv | 1:0 (1:0) | |
| 18:00 | Rukh Lviv | - | Olimpik Donetsk | 3:0 (3:0) | ||
| 18:30 | FC Mynai | - | Shakhtar Donetsk | 0:4 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 25 | 19 | 5 | 1 | 56:15 | 41 | 62 |
| 2 |
|
Shakhtar Donetsk | 25 | 15 | 6 | 4 | 53:19 | 34 | 51 |
| 3 |
|
Zorya Lugansk | 25 | 14 | 5 | 6 | 42:21 | 21 | 47 |
| 4 |
|
Kolos Kovalivka | 25 | 10 | 11 | 4 | 36:23 | 13 | 41 |
| 5 |
|
Desna Chernigov | 25 | 10 | 8 | 7 | 37:28 | 9 | 38 |
| 6 |
|
Vorskla Poltava | 25 | 10 | 8 | 7 | 35:29 | 6 | 38 |
| 7 |
|
SK Dnipro-1 | 25 | 8 | 5 | 12 | 35:37 | -2 | 29 |
| 8 |
|
FK Oleksandriya | 25 | 8 | 5 | 12 | 32:35 | -3 | 29 |
| 9 |
|
FK Lviv | 25 | 8 | 4 | 13 | 24:50 | -26 | 28 |
| 10 |
|
Rukh Lviv | 25 | 6 | 9 | 10 | 26:38 | -12 | 27 |
| 11 |
|
Inhulets Petrove | 25 | 5 | 11 | 9 | 24:38 | -14 | 26 |
| 12 |
|
FK Mariupol | 25 | 5 | 8 | 12 | 23:40 | -17 | 23 |
| 13 |
|
Olimpik Donetsk | 25 | 6 | 3 | 16 | 27:47 | -20 | 21 |
| 14 |
|
FC Mynai | 25 | 4 | 6 | 15 | 15:45 | -30 | 18 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
