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| 08.03.2022 | 12:00 | Kahramanmaraşspor | - | Sivas Belediyespor | 0:0 (0:0) | |
| 09.03.2022 | 11:00 | Serik Belediyespor | - | Bayburt İl Özel İdare | 1:1 (0:1) | |
| 12:00 | Adıyamanspor | - | Ankaraspor | 0:3 (0:1) | ||
| 12:00 | Afjet Afyonspor | - | Somaspor | 4:1 (2:1) | ||
| 12:00 | Diyarbekirspor | - | Vanspor FK | 0:1 (0:1) | ||
| 12:00 | Ergene Velimeşe | - | Bodrumspor | 2:0 (2:0) | ||
| 12:00 | Etimesgut Belediyespor | - | Inegölspor | 2:3 (2:1) | ||
| 12:00 | Niğde Anadolu FK | - | 1461 Trabzon FK | 1:4 (1:2) | ||
| 12:00 | Sakaryaspor | - | Çorum FK | 4:1 (1:0) | ||
| 12:00 | Turgutluspor | - | Sarıyer SK | 0:2 (0:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 22 | 15 | 6 | 1 | 48:13 | 35 | 51 |
| 2 |
|
1461 Trabzon FK | 22 | 13 | 7 | 2 | 37:17 | 20 | 46 |
| 3 |
|
Sivas Belediyespor | 22 | 12 | 5 | 5 | 41:19 | 22 | 41 |
| 4 |
|
Afjet Afyonspor | 22 | 11 | 7 | 4 | 45:26 | 19 | 40 |
| 5 |
|
Bayburt İl Özel İdare | 22 | 11 | 5 | 6 | 29:22 | 7 | 38 |
| 6 |
|
Vanspor FK | 22 | 11 | 5 | 6 | 31:29 | 2 | 38 |
| 7 |
|
Bodrumspor | 22 | 11 | 4 | 7 | 33:20 | 13 | 37 |
| 8 |
|
Somaspor | 22 | 10 | 5 | 7 | 35:30 | 5 | 35 |
| 9 |
|
Ankaraspor | 22 | 9 | 7 | 6 | 37:26 | 11 | 34 |
| 10 |
|
Çorum FK | 22 | 9 | 7 | 6 | 30:20 | 10 | 34 |
| 11 |
|
Serik Belediyespor | 22 | 9 | 3 | 10 | 29:31 | -2 | 30 |
| 12 |
|
Inegölspor | 22 | 9 | 3 | 10 | 27:31 | -4 | 30 |
| 13 |
|
Diyarbekirspor | 22 | 7 | 4 | 11 | 24:26 | -2 | 25 |
| 14 |
|
Etimesgut Belediyespor | 22 | 6 | 7 | 9 | 24:30 | -6 | 25 |
| 15 |
|
Turgutluspor | 22 | 5 | 8 | 9 | 20:34 | -14 | 23 |
| 16 |
|
Adıyamanspor | 22 | 7 | 1 | 14 | 29:41 | -12 | 22 |
| 17 |
|
Sarıyer SK | 22 | 6 | 3 | 13 | 24:34 | -10 | 21 |
| 18 |
|
Ergene Velimeşe | 22 | 6 | 3 | 13 | 24:42 | -18 | 21 |
| 19 |
|
Kahramanmaraşspor | 22 | 3 | 4 | 15 | 15:51 | -36 | 13 |
| 20 |
|
Niğde Anadolu FK | 22 | 1 | 4 | 17 | 14:54 | -40 | 7 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
