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| H | BSC Young Boys | - | FC Zürich Frauen | 1:2 (1:0) | ||
| R | FC Zürich Frauen | - | BSC Young Boys | 7:0 (1:0) | ||
| H: 07.05.2022 15:30 | R: 14.05.2022 14:30 | Sieger: FC Zürich Frauen | ||||
| H | FC Aarau | - | Servette FCCF | 0:1 (0:1) | ||
| R | Servette FCCF | - | FC Aarau | 4:0 (2:0) | ||
| H: 07.05.2022 16:00 | R: 14.05.2022 18:00 | Sieger: Servette FCCF | ||||
| H | FC Luzern | - | Grasshopper Club Zürich | 2:5 (2:4) | ||
| R | Grasshopper Club Zürich | - | FC Luzern | 3:3 (1:2) | ||
| H: 07.05.2022 18:00 | R: 14.05.2022 19:00 | Sieger: Grasshopper Club Zürich | ||||
| H | FC St. Gallen | - | FC Basel | 0:3 (0:0) | ||
| R | FC Basel | - | FC St. Gallen | 4:1 (0:1) | ||
| H: 08.05.2022 16:00 | R: 14.05.2022 18:00 | Sieger: FC Basel | ||||
