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| 07.05.2022 | 11:00 | Kuban Krasnodar | - | CSKA Moskva | 2:2 (1:0) | |
| 13:00 | Spartak Moskva | - | FK Strogino Moskva | 1:1 (0:0) | ||
| 13:00 | FK Saturn | - | Chertanovo Football Academy | 0:3 (0:0) | ||
| 13:00 | FK Krasnodar | - | FK Rostov | 1:1 (0:0) | ||
| 13:00 | FShM Moskva | - | Rubin Kazan | 2:0 (1:0) | ||
| 14:00 | Zenit St. Petersburg | - | SShOR Zenit | 3:0 (2:0) | ||
| 16:00 | Dinamo Moskva | - | Lokomotiv Moskva | 2:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Spartak Moskva | 24 | 17 | 4 | 3 | 62:18 | 44 | 55 |
| 2 |
|
FK Krasnodar | 24 | 16 | 5 | 3 | 58:22 | 36 | 53 |
| 3 |
|
Zenit St. Petersburg | 24 | 15 | 4 | 5 | 66:34 | 32 | 49 |
| 4 |
|
FK Rostov | 24 | 14 | 6 | 4 | 43:22 | 21 | 48 |
| 5 |
|
Chertanovo Football Academy | 24 | 14 | 3 | 7 | 56:35 | 21 | 45 |
| 6 |
|
FK Strogino Moskva | 24 | 13 | 2 | 9 | 41:33 | 8 | 41 |
| 7 |
|
Lokomotiv Moskva | 24 | 10 | 2 | 12 | 43:52 | -9 | 32 |
| 8 |
|
CSKA Moskva | 24 | 8 | 5 | 11 | 47:52 | -5 | 29 |
| 9 |
|
FK Saturn | 24 | 8 | 4 | 12 | 38:60 | -22 | 28 |
| 10 |
|
SShOR Zenit | 24 | 7 | 4 | 13 | 31:47 | -16 | 25 |
| 11 |
|
Kuban Krasnodar | 24 | 5 | 8 | 11 | 23:48 | -25 | 23 |
| 12 |
|
FShM Moskva | 24 | 4 | 5 | 15 | 28:63 | -35 | 17 |
| 13 |
|
Dinamo Moskva | 24 | 4 | 4 | 16 | 30:55 | -25 | 16 |
| 14 |
|
Rubin Kazan | 24 | 2 | 6 | 16 | 20:45 | -25 | 12 |
