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| 12.03.2022 | 12:00 | FK Krasnodar | - | Spartak Moskva | 1:1 (1:0) | |
| 12:00 | FShM Moskva | - | CSKA Moskva | 1:3 (1:0) | ||
| 12:00 | FK Strogino Moskva | - | SShOR Zenit | 3:1 (2:0) | ||
| 12:00 | FK Rostov | - | Chertanovo Football Academy | 1:1 (0:0) | ||
| 13:00 | Zenit St. Petersburg | - | Dinamo Moskva | 5:1 (1:1) | ||
| 15:30 | Lokomotiv Moskva | - | Rubin Kazan | 2:0 (1:0) | ||
| 13.03.2022 | 10:00 | Kuban Krasnodar | - | FK Saturn | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Spartak Moskva | 18 | 12 | 3 | 3 | 47:14 | 33 | 39 |
| 2 |
|
FK Krasnodar | 18 | 12 | 3 | 3 | 42:16 | 26 | 39 |
| 3 |
|
Zenit St. Petersburg | 18 | 11 | 3 | 4 | 51:28 | 23 | 36 |
| 4 |
|
Chertanovo Football Academy | 18 | 11 | 2 | 5 | 42:27 | 15 | 35 |
| 5 |
|
FK Rostov | 18 | 10 | 5 | 3 | 29:17 | 12 | 35 |
| 6 |
|
FK Strogino Moskva | 18 | 10 | 1 | 7 | 32:23 | 9 | 31 |
| 7 |
|
Lokomotiv Moskva | 18 | 9 | 2 | 7 | 34:32 | 2 | 29 |
| 8 |
|
FK Saturn | 18 | 6 | 4 | 8 | 27:43 | -16 | 22 |
| 9 |
|
SShOR Zenit | 18 | 6 | 3 | 9 | 28:34 | -6 | 21 |
| 10 |
|
CSKA Moskva | 18 | 6 | 3 | 9 | 32:39 | -7 | 21 |
| 11 |
|
Kuban Krasnodar | 18 | 4 | 5 | 9 | 16:39 | -23 | 17 |
| 12 |
|
Dinamo Moskva | 18 | 3 | 3 | 12 | 23:41 | -18 | 12 |
| 13 |
|
FShM Moskva | 18 | 2 | 4 | 12 | 19:49 | -30 | 10 |
| 14 |
|
Rubin Kazan | 18 | 1 | 5 | 12 | 17:37 | -20 | 8 |
