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| 06.03.2021 | 14:00 | Bonner SC | - | SV Lippstadt 08 | 0:0 (0:0) | |
| 14:00 | FC Wegberg-Beeck | - | Borussia Dortmund II | 0:2 (0:0) | ||
| 14:00 | Rot-Weiß Oberhausen | - | Alemannia Aachen | 3:1 (2:0) | ||
| 14:00 | SC Wiedenbrück | - | Fortuna Düsseldorf II | 0:2 (0:0) | ||
| 14:00 | Sportfreunde Lotte | - | Preußen Münster | 1:1 (0:0) | ||
| 14:00 | SV 19 Straelen | - | SV Bergisch Gladbach 09 | 3:1 (0:1) | ||
| 14:00 | VfB Homberg | - | SV Rödinghausen | 0:2 (0:1) | ||
| 14:00 | Wuppertaler SV | - | FC Schalke 04 II | 2:0 (1:0) | ||
| 15:00 | 1. FC Köln II | - | Bor. Mönchengladbach II | 2:0 (1:0) | ||
| 07.03.2021 | 14:00 | Rot-Weiss Essen | - | Fortuna Köln | 2:0 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 27 | 19 | 7 | 1 | 70:20 | 50 | 64 |
| 2 |
|
Rot-Weiss Essen | 27 | 18 | 7 | 2 | 57:18 | 39 | 61 |
| 3 |
|
Preußen Münster | 28 | 17 | 5 | 6 | 45:24 | 21 | 56 |
| 4 |
|
Fortuna Düsseldorf II | 28 | 15 | 6 | 7 | 56:29 | 27 | 51 |
| 5 |
|
Fortuna Köln | 28 | 13 | 10 | 5 | 50:32 | 18 | 49 |
| 6 |
|
Rot-Weiß Oberhausen | 28 | 11 | 10 | 7 | 45:34 | 11 | 43 |
| 7 |
|
SV Rödinghausen | 28 | 12 | 7 | 9 | 37:30 | 7 | 43 |
| 8 |
|
1. FC Köln II | 27 | 11 | 8 | 8 | 42:34 | 8 | 41 |
| 9 |
|
Bor. Mönchengladbach II | 28 | 12 | 5 | 11 | 37:35 | 2 | 41 |
| 10 |
|
FC Schalke 04 II | 28 | 9 | 10 | 9 | 31:30 | 1 | 37 |
| 11 |
|
SV 19 Straelen | 28 | 10 | 7 | 11 | 33:41 | -8 | 37 |
| 12 |
|
Alemannia Aachen | 28 | 9 | 8 | 11 | 25:31 | -6 | 35 |
| 13 |
|
SC Wiedenbrück | 27 | 7 | 13 | 7 | 34:36 | -2 | 34 |
| 14 |
|
Wuppertaler SV | 28 | 9 | 4 | 15 | 31:48 | -17 | 31 |
| 15 |
|
FC Wegberg-Beeck | 27 | 6 | 8 | 13 | 25:42 | -17 | 26 |
| 16 |
|
SV Lippstadt 08 | 28 | 5 | 11 | 12 | 28:47 | -19 | 26 |
| 17 |
|
VfB Homberg | 28 | 7 | 5 | 16 | 26:49 | -23 | 26 |
| 18 |
|
SV Bergisch Gladbach 09 | 28 | 6 | 7 | 15 | 27:48 | -21 | 25 |
| 19 |
|
Sportfreunde Lotte | 27 | 5 | 9 | 13 | 25:51 | -26 | 24 |
| 20 |
|
Bonner SC | 27 | 5 | 5 | 17 | 25:50 | -25 | 20 |
| 21 |
|
Rot Weiss Ahlen | 27 | 3 | 10 | 14 | 29:49 | -20 | 19 |
| Aufstieg | |
| Abstieg |
