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| 26.02.2021 | 19:00 | Fortuna Düsseldorf II | - | Rot-Weiss Essen | 3:0 (1:0) | |
| 27.02.2021 | 14:00 | Bor. Mönchengladbach II | - | Alemannia Aachen | 1:2 (0:1) | |
| 14:00 | FC Schalke 04 II | - | VfB Homberg | 2:0 (0:0) | ||
| 14:00 | Fortuna Köln | - | Sportfreunde Lotte | 2:2 (1:0) | ||
| 14:00 | Preußen Münster | - | 1. FC Köln II | 3:2 (1:1) | ||
| 14:00 | Rot Weiss Ahlen | - | Bonner SC | 1:2 (0:0) | ||
| 14:00 | Rot-Weiß Oberhausen | - | Wuppertaler SV | 3:0 (1:0) | ||
| 14:00 | SV Bergisch Gladbach 09 | - | FC Wegberg-Beeck | 3:0 (1:0) | ||
| 14:00 | SV Lippstadt 08 | - | SC Wiedenbrück | 0:1 (0:0) | ||
| 14:00 | SV Rödinghausen | - | SV 19 Straelen | 0:1 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 26 | 18 | 7 | 1 | 68:20 | 48 | 61 |
| 2 |
|
Rot-Weiss Essen | 26 | 17 | 7 | 2 | 55:18 | 37 | 58 |
| 3 |
|
Preußen Münster | 27 | 17 | 4 | 6 | 44:23 | 21 | 55 |
| 4 |
|
Fortuna Köln | 27 | 13 | 10 | 4 | 50:30 | 20 | 49 |
| 5 |
|
Fortuna Düsseldorf II | 27 | 14 | 6 | 7 | 54:29 | 25 | 48 |
| 6 |
|
Bor. Mönchengladbach II | 27 | 12 | 5 | 10 | 37:33 | 4 | 41 |
| 7 |
|
Rot-Weiß Oberhausen | 27 | 10 | 10 | 7 | 42:33 | 9 | 40 |
| 8 |
|
SV Rödinghausen | 27 | 11 | 7 | 9 | 35:30 | 5 | 40 |
| 9 |
|
1. FC Köln II | 26 | 10 | 8 | 8 | 40:34 | 6 | 38 |
| 10 |
|
FC Schalke 04 II | 27 | 9 | 10 | 8 | 31:28 | 3 | 37 |
| 11 |
|
Alemannia Aachen | 27 | 9 | 8 | 10 | 24:28 | -4 | 35 |
| 12 |
|
SC Wiedenbrück | 26 | 7 | 13 | 6 | 34:34 | 0 | 34 |
| 13 |
|
SV 19 Straelen | 27 | 9 | 7 | 11 | 30:40 | -10 | 34 |
| 14 |
|
Wuppertaler SV | 27 | 8 | 4 | 15 | 29:48 | -19 | 28 |
| 15 |
|
FC Wegberg-Beeck | 26 | 6 | 8 | 12 | 25:40 | -15 | 26 |
| 16 |
|
VfB Homberg | 27 | 7 | 5 | 15 | 26:47 | -21 | 26 |
| 17 |
|
SV Lippstadt 08 | 27 | 5 | 10 | 12 | 28:47 | -19 | 25 |
| 18 |
|
SV Bergisch Gladbach 09 | 27 | 6 | 7 | 14 | 26:45 | -19 | 25 |
| 19 |
|
Sportfreunde Lotte | 26 | 5 | 8 | 13 | 24:50 | -26 | 23 |
| 20 |
|
Rot Weiss Ahlen | 27 | 3 | 10 | 14 | 29:49 | -20 | 19 |
| 21 |
|
Bonner SC | 26 | 5 | 4 | 17 | 25:50 | -25 | 19 |
| Aufstieg | |
| Abstieg |
