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| 07.05.2022 | 14:00 | Bahlinger SC | - | 1. FSV Mainz 05 II | 0:2 (0:0) | |
| 14:00 | FC Gießen | - | 1899 Hoffenheim II | 1:2 (1:0) | ||
| 14:00 | FK Pirmasens | - | TSV Schott Mainz | 2:1 (2:1) | ||
| 14:00 | FSV Frankfurt | - | SV 07 Elversberg | 1:1 (1:1) | ||
| 14:00 | SG Sonnenhof Großaspach | - | SSV Ulm 1846 | 3:1 (0:0) | ||
| 14:00 | TSG Balingen | - | FC-Astoria Walldorf | 3:2 (2:0) | ||
| 14:00 | TSV Steinbach Haiger | - | Rot-Weiß Koblenz | 2:1 (1:1) | ||
| 14:00 | VfB Stuttgart II | - | Kickers Offenbach | 2:4 (2:3) | ||
| 14:00 | VfR Aalen | - | Hessen Kassel | 0:0 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV 07 Elversberg | 35 | 23 | 8 | 4 | 77:29 | 48 | 77 |
| 2 |
|
SSV Ulm 1846 | 35 | 22 | 8 | 5 | 57:28 | 29 | 74 |
| 3 |
|
Kickers Offenbach | 35 | 23 | 4 | 8 | 63:26 | 37 | 73 |
| 4 |
|
TSV Steinbach Haiger | 35 | 19 | 10 | 6 | 60:35 | 25 | 67 |
| 5 |
|
1. FSV Mainz 05 II | 35 | 21 | 3 | 11 | 60:40 | 20 | 66 |
| 6 |
|
FC 08 Homburg | 35 | 14 | 10 | 11 | 43:46 | -3 | 52 |
| 7 |
|
Hessen Kassel | 35 | 12 | 12 | 11 | 43:37 | 6 | 48 |
| 8 |
|
TSG Balingen | 35 | 13 | 7 | 15 | 44:61 | -17 | 46 |
| 9 |
|
Bahlinger SC | 35 | 12 | 9 | 14 | 35:41 | -6 | 45 |
| 10 |
|
FC-Astoria Walldorf | 35 | 12 | 8 | 15 | 49:59 | -10 | 44 |
| 11 |
|
VfB Stuttgart II | 35 | 12 | 7 | 16 | 47:49 | -2 | 43 |
| 12 |
|
1899 Hoffenheim II | 35 | 10 | 11 | 14 | 45:48 | -3 | 41 |
| 13 |
|
VfR Aalen | 35 | 11 | 7 | 17 | 47:60 | -13 | 40 |
| 14 |
|
Rot-Weiß Koblenz | 35 | 9 | 12 | 14 | 36:43 | -7 | 39 |
| 15 |
|
FSV Frankfurt | 35 | 9 | 12 | 14 | 40:49 | -9 | 39 |
| 16 |
|
SG Sonnenhof Großaspach | 35 | 10 | 6 | 19 | 41:64 | -23 | 36 |
| 17 |
|
FK Pirmasens | 36 | 9 | 6 | 21 | 32:59 | -27 | 33 |
| 18 |
|
TSV Schott Mainz | 35 | 8 | 6 | 21 | 33:58 | -25 | 30 |
| 19 |
|
FC Gießen | 35 | 7 | 8 | 20 | 28:48 | -20 | 29 |
| Aufstieg | |
| Abstieg |
