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| 05.06.2021 | 14:00 | Bahlinger SC | - | FK Pirmasens | 0:2 (0:1) | |
| 14:00 | Eintracht Stadtallendorf | - | FC Gießen | 1:3 (0:1) | ||
| 14:00 | FC 08 Homburg | - | Bayern Alzenau | 3:0 (0:0) | ||
| 14:00 | FC-Astoria Walldorf | - | 1899 Hoffenheim II | 3:4 (2:2) | ||
| 14:00 | FSV Frankfurt | - | TSG Balingen | 0:2 (0:2) | ||
| 14:00 | 1. FSV Mainz 05 II | - | SG Sonnenhof Großaspach | 0:1 (0:1) | ||
| 14:00 | Hessen Kassel | - | SSV Ulm 1846 | 3:1 (3:0) | ||
| 14:00 | Rot-Weiß Koblenz | - | TSV Steinbach Haiger | 3:1 (0:1) | ||
| 14:00 | SV 07 Elversberg | - | SC Freiburg II | 1:1 (1:0) | ||
| 14:00 | TSV Schott Mainz | - | VfB Stuttgart II | 2:4 (0:1) | ||
| 14:00 | VfR Aalen | - | Kickers Offenbach | 0:2 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 41 | 27 | 9 | 5 | 93:38 | 55 | 90 |
| 2 |
|
SV 07 Elversberg | 41 | 24 | 13 | 4 | 95:42 | 53 | 85 |
| 3 |
|
Kickers Offenbach | 41 | 24 | 12 | 5 | 79:32 | 47 | 84 |
| 4 |
|
SSV Ulm 1846 | 41 | 23 | 10 | 8 | 75:38 | 37 | 79 |
| 5 |
|
TSV Steinbach Haiger | 41 | 21 | 10 | 10 | 81:44 | 37 | 73 |
| 6 |
|
FSV Frankfurt | 41 | 20 | 9 | 12 | 55:45 | 10 | 69 |
| 7 |
|
FC 08 Homburg | 41 | 17 | 14 | 10 | 71:53 | 18 | 65 |
| 8 |
|
VfB Stuttgart II | 41 | 18 | 8 | 15 | 75:54 | 21 | 62 |
| 9 |
|
Bahlinger SC | 41 | 16 | 10 | 15 | 63:74 | -11 | 58 |
| 10 |
|
Rot-Weiß Koblenz | 41 | 15 | 11 | 15 | 57:59 | -2 | 56 |
| 11 |
|
Hessen Kassel | 41 | 13 | 14 | 14 | 56:68 | -12 | 53 |
| 12 |
|
TSG Balingen | 41 | 14 | 9 | 18 | 51:59 | -8 | 51 |
| 13 |
|
FC Gießen | 41 | 12 | 14 | 15 | 49:50 | -1 | 50 |
| 14 |
|
1899 Hoffenheim II | 41 | 13 | 11 | 17 | 57:72 | -15 | 50 |
| 15 |
|
VfR Aalen | 41 | 12 | 13 | 16 | 45:58 | -13 | 49 |
| 16 |
|
1. FSV Mainz 05 II | 41 | 13 | 10 | 18 | 58:72 | -14 | 49 |
| 17 |
|
FK Pirmasens | 41 | 12 | 13 | 16 | 41:58 | -17 | 49 |
| 18 |
|
FC-Astoria Walldorf | 41 | 13 | 5 | 23 | 63:79 | -16 | 44 |
| 19 |
|
SG Sonnenhof Großaspach | 41 | 11 | 10 | 20 | 51:72 | -21 | 43 |
| 20 |
|
TSV Schott Mainz | 41 | 11 | 5 | 25 | 55:101 | -46 | 38 |
| 21 |
|
Bayern Alzenau | 41 | 5 | 10 | 26 | 47:91 | -44 | 25 |
| 22 |
|
Eintracht Stadtallendorf | 41 | 3 | 8 | 30 | 39:97 | -58 | 17 |
| Aufstieg | |
| Abstieg |
