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| 29.05.2021 | 14:00 | Bahlinger SC | - | 1. FSV Mainz 05 II | 2:1 (1:0) | |
| 14:00 | Bayern Alzenau | - | Hessen Kassel | 0:1 (0:1) | ||
| 14:00 | FC Gießen | - | TSV Schott Mainz | 5:0 (1:0) | ||
| 14:00 | SC Freiburg II | - | FC 08 Homburg | 0:1 (0:0) | ||
| 14:00 | SG Sonnenhof Großaspach | - | VfR Aalen | 3:2 (1:1) | ||
| 14:00 | 1899 Hoffenheim II | - | FSV Frankfurt | 1:0 (0:0) | ||
| 14:00 | VfB Stuttgart II | - | FK Pirmasens | 3:1 (0:0) | ||
| 01.06.2021 | 19:00 | Kickers Offenbach | - | FC-Astoria Walldorf | 6:1 (2:1) | |
| 19:00 | SSV Ulm 1846 | - | Eintracht Stadtallendorf | 2:2 (1:1) | ||
| 19:00 | TSG Balingen | - | Rot-Weiß Koblenz | 3:1 (1:1) | ||
| 19:00 | TSV Steinbach Haiger | - | SV 07 Elversberg | 1:2 (1:2) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 40 | 27 | 8 | 5 | 92:37 | 55 | 89 |
| 2 |
|
SV 07 Elversberg | 40 | 24 | 12 | 4 | 94:41 | 53 | 84 |
| 3 |
|
Kickers Offenbach | 40 | 23 | 12 | 5 | 77:32 | 45 | 81 |
| 4 |
|
SSV Ulm 1846 | 40 | 23 | 10 | 7 | 74:35 | 39 | 79 |
| 5 |
|
TSV Steinbach Haiger | 40 | 21 | 10 | 9 | 80:41 | 39 | 73 |
| 6 |
|
FSV Frankfurt | 40 | 20 | 9 | 11 | 55:43 | 12 | 69 |
| 7 |
|
FC 08 Homburg | 40 | 16 | 14 | 10 | 68:53 | 15 | 62 |
| 8 |
|
VfB Stuttgart II | 40 | 17 | 8 | 15 | 71:52 | 19 | 59 |
| 9 |
|
Bahlinger SC | 40 | 16 | 10 | 14 | 63:72 | -9 | 58 |
| 10 |
|
Rot-Weiß Koblenz | 40 | 14 | 11 | 15 | 54:58 | -4 | 53 |
| 11 |
|
Hessen Kassel | 40 | 12 | 14 | 14 | 53:67 | -14 | 50 |
| 12 |
|
VfR Aalen | 40 | 12 | 13 | 15 | 45:56 | -11 | 49 |
| 13 |
|
1. FSV Mainz 05 II | 40 | 13 | 10 | 17 | 58:71 | -13 | 49 |
| 14 |
|
TSG Balingen | 40 | 13 | 9 | 18 | 49:59 | -10 | 48 |
| 15 |
|
FC Gießen | 40 | 11 | 14 | 15 | 46:49 | -3 | 47 |
| 16 |
|
1899 Hoffenheim II | 40 | 12 | 11 | 17 | 53:69 | -16 | 47 |
| 17 |
|
FK Pirmasens | 40 | 11 | 13 | 16 | 39:58 | -19 | 46 |
| 18 |
|
FC-Astoria Walldorf | 40 | 13 | 5 | 22 | 60:75 | -15 | 44 |
| 19 |
|
SG Sonnenhof Großaspach | 40 | 10 | 10 | 20 | 50:72 | -22 | 40 |
| 20 |
|
TSV Schott Mainz | 40 | 11 | 5 | 24 | 53:97 | -44 | 38 |
| 21 |
|
Bayern Alzenau | 40 | 5 | 10 | 25 | 47:88 | -41 | 25 |
| 22 |
|
Eintracht Stadtallendorf | 40 | 3 | 8 | 29 | 38:94 | -56 | 17 |
| Aufstieg | |
| Abstieg |
