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| 20.04.2021 | 14:00 | VfB Stuttgart II | - | 1899 Hoffenheim II | 2:1 (0:0) | |
| 18:00 | FC 08 Homburg | - | 1. FSV Mainz 05 II | 2:2 (1:1) | ||
| 18:00 | Bayern Alzenau | - | SC Freiburg II | 1:3 (1:1) | ||
| 18:00 | FC Gießen | - | TSG Balingen | 3:0 (1:0) | ||
| 19:00 | Eintracht Stadtallendorf | - | SG Sonnenhof Großaspach | 0:2 (0:0) | ||
| 19:00 | FK Pirmasens | - | FSV Frankfurt | 0:1 (0:0) | ||
| 19:00 | Rot-Weiß Koblenz | - | FC-Astoria Walldorf | 3:2 (0:0) | ||
| 19:00 | TSV Schott Mainz | - | Kickers Offenbach | 2:4 (0:0) | ||
| 21.04.2021 | 17:00 | Hessen Kassel | - | Bahlinger SC | 1:1 (1:0) | |
| 18:30 | SV 07 Elversberg | - | VfR Aalen | 2:1 (2:0) | ||
| 18.05.2021 | 19:00 | SSV Ulm 1846 | - | TSV Steinbach Haiger | 2:1 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 33 | 22 | 7 | 4 | 77:33 | 44 | 73 |
| 2 |
|
SSV Ulm 1846 | 33 | 19 | 8 | 6 | 63:28 | 35 | 65 |
| 3 |
|
Kickers Offenbach | 33 | 18 | 11 | 4 | 56:24 | 32 | 65 |
| 4 |
|
SV 07 Elversberg | 33 | 17 | 12 | 4 | 75:35 | 40 | 63 |
| 5 |
|
TSV Steinbach Haiger | 33 | 17 | 9 | 7 | 66:34 | 32 | 60 |
| 6 |
|
FSV Frankfurt | 33 | 17 | 8 | 8 | 45:34 | 11 | 59 |
| 7 |
|
Bahlinger SC | 33 | 14 | 8 | 11 | 50:57 | -7 | 50 |
| 8 |
|
VfB Stuttgart II | 33 | 14 | 7 | 12 | 60:41 | 19 | 49 |
| 9 |
|
FC 08 Homburg | 33 | 12 | 13 | 8 | 57:45 | 12 | 49 |
| 10 |
|
Rot-Weiß Koblenz | 33 | 13 | 8 | 12 | 42:44 | -2 | 47 |
| 11 |
|
1. FSV Mainz 05 II | 33 | 12 | 9 | 12 | 48:52 | -4 | 45 |
| 12 |
|
TSG Balingen | 33 | 11 | 8 | 14 | 41:46 | -5 | 41 |
| 13 |
|
VfR Aalen | 33 | 10 | 11 | 12 | 36:45 | -9 | 41 |
| 14 |
|
Hessen Kassel | 33 | 10 | 10 | 13 | 45:57 | -12 | 40 |
| 15 |
|
FC Gießen | 33 | 9 | 12 | 12 | 36:39 | -3 | 39 |
| 16 |
|
SG Sonnenhof Großaspach | 33 | 9 | 10 | 14 | 42:56 | -14 | 37 |
| 17 |
|
FK Pirmasens | 33 | 8 | 13 | 12 | 29:48 | -19 | 37 |
| 18 |
|
1899 Hoffenheim II | 33 | 9 | 8 | 16 | 43:61 | -18 | 35 |
| 19 |
|
TSV Schott Mainz | 33 | 9 | 5 | 19 | 46:79 | -33 | 32 |
| 20 |
|
FC-Astoria Walldorf | 33 | 9 | 4 | 20 | 45:61 | -16 | 31 |
| 21 |
|
Bayern Alzenau | 33 | 5 | 7 | 21 | 39:72 | -33 | 22 |
| 22 |
|
Eintracht Stadtallendorf | 33 | 2 | 6 | 25 | 26:76 | -50 | 12 |
| Aufstieg | |
| Abstieg |
