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| 10.04.2021 | 14:00 | Eintracht Stadtallendorf | - | 1. FSV Mainz 05 II | 3:2 (2:0) | |
| 14:00 | FC 08 Homburg | - | FC-Astoria Walldorf | 3:1 (1:0) | ||
| 14:00 | Bayern Alzenau | - | TSG Balingen | 2:3 (0:2) | ||
| 14:00 | FC Gießen | - | Kickers Offenbach | 0:2 (0:1) | ||
| 14:00 | FK Pirmasens | - | Rot-Weiß Koblenz | 1:1 (1:0) | ||
| 14:00 | Hessen Kassel | - | VfR Aalen | 1:1 (1:0) | ||
| 14:00 | SSV Ulm 1846 | - | 1899 Hoffenheim II | 4:1 (1:1) | ||
| 14:00 | SV 07 Elversberg | - | FSV Frankfurt | 2:2 (2:1) | ||
| 14:00 | TSV Schott Mainz | - | Bahlinger SC | 3:1 (3:1) | ||
| 14:00 | VfB Stuttgart II | - | SG Sonnenhof Großaspach | 0:2 (0:1) | ||
| 11.04.2021 | 14:00 | SC Freiburg II | - | TSV Steinbach Haiger | 1:0 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 31 | 20 | 7 | 4 | 73:32 | 41 | 67 |
| 2 |
|
Kickers Offenbach | 31 | 17 | 10 | 4 | 51:21 | 30 | 61 |
| 3 |
|
SSV Ulm 1846 | 31 | 17 | 8 | 6 | 57:27 | 30 | 59 |
| 4 |
|
SV 07 Elversberg | 31 | 15 | 12 | 4 | 69:33 | 36 | 57 |
| 5 |
|
TSV Steinbach Haiger | 31 | 16 | 9 | 6 | 61:32 | 29 | 57 |
| 6 |
|
FSV Frankfurt | 31 | 16 | 8 | 7 | 43:32 | 11 | 56 |
| 7 |
|
FC 08 Homburg | 31 | 12 | 11 | 8 | 54:42 | 12 | 47 |
| 8 |
|
Bahlinger SC | 31 | 13 | 7 | 11 | 48:56 | -8 | 46 |
| 9 |
|
VfB Stuttgart II | 31 | 13 | 6 | 12 | 57:39 | 18 | 45 |
| 10 |
|
TSG Balingen | 31 | 11 | 8 | 12 | 41:39 | 2 | 41 |
| 11 |
|
Rot-Weiß Koblenz | 31 | 11 | 8 | 12 | 37:41 | -4 | 41 |
| 12 |
|
1. FSV Mainz 05 II | 31 | 11 | 8 | 12 | 44:49 | -5 | 41 |
| 13 |
|
VfR Aalen | 31 | 10 | 10 | 11 | 34:42 | -8 | 40 |
| 14 |
|
Hessen Kassel | 31 | 10 | 9 | 12 | 43:54 | -11 | 39 |
| 15 |
|
FK Pirmasens | 31 | 8 | 13 | 10 | 29:46 | -17 | 37 |
| 16 |
|
FC Gießen | 31 | 8 | 11 | 12 | 31:37 | -6 | 35 |
| 17 |
|
SG Sonnenhof Großaspach | 31 | 8 | 10 | 13 | 39:52 | -13 | 34 |
| 18 |
|
1899 Hoffenheim II | 31 | 9 | 7 | 15 | 40:57 | -17 | 34 |
| 19 |
|
FC-Astoria Walldorf | 31 | 9 | 4 | 18 | 42:54 | -12 | 31 |
| 20 |
|
TSV Schott Mainz | 31 | 8 | 5 | 18 | 40:74 | -34 | 29 |
| 21 |
|
Bayern Alzenau | 31 | 5 | 7 | 19 | 38:65 | -27 | 22 |
| 22 |
|
Eintracht Stadtallendorf | 31 | 2 | 6 | 23 | 26:73 | -47 | 12 |
| Aufstieg | |
| Abstieg |
