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| 03.04.2021 | 14:00 | Bahlinger SC | - | VfB Stuttgart II | 1:0 (0:0) | |
| 14:00 | FC-Astoria Walldorf | - | Hessen Kassel | 1:2 (0:2) | ||
| 14:00 | FSV Frankfurt | - | FC 08 Homburg | 0:0 (0:0) | ||
| 14:00 | Kickers Offenbach | - | SSV Ulm 1846 | 1:0 (1:0) | ||
| 14:00 | Rot-Weiß Koblenz | - | SV 07 Elversberg | 1:1 (1:0) | ||
| 14:00 | SG Sonnenhof Großaspach | - | FC Gießen | 1:1 (0:1) | ||
| 14:00 | TSG Balingen | - | SC Freiburg II | 0:1 (0:0) | ||
| 14:00 | 1899 Hoffenheim II | - | Bayern Alzenau | 4:2 (2:0) | ||
| 14:00 | TSV Steinbach Haiger | - | FK Pirmasens | 1:1 (0:0) | ||
| 14:00 | VfR Aalen | - | Eintracht Stadtallendorf | 2:1 (2:1) | ||
| 04.04.2021 | 14:00 | 1. FSV Mainz 05 II | - | TSV Schott Mainz | 3:1 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 30 | 19 | 7 | 4 | 72:32 | 40 | 64 |
| 2 |
|
Kickers Offenbach | 30 | 16 | 10 | 4 | 49:21 | 28 | 58 |
| 3 |
|
TSV Steinbach Haiger | 30 | 16 | 9 | 5 | 61:31 | 30 | 57 |
| 4 |
|
SV 07 Elversberg | 30 | 15 | 11 | 4 | 67:31 | 36 | 56 |
| 5 |
|
SSV Ulm 1846 | 30 | 16 | 8 | 6 | 53:26 | 27 | 56 |
| 6 |
|
FSV Frankfurt | 30 | 16 | 7 | 7 | 41:30 | 11 | 55 |
| 7 |
|
Bahlinger SC | 30 | 13 | 7 | 10 | 47:53 | -6 | 46 |
| 8 |
|
VfB Stuttgart II | 30 | 13 | 6 | 11 | 57:37 | 20 | 45 |
| 9 |
|
FC 08 Homburg | 30 | 11 | 11 | 8 | 51:41 | 10 | 44 |
| 10 |
|
1. FSV Mainz 05 II | 30 | 11 | 8 | 11 | 42:46 | -4 | 41 |
| 11 |
|
Rot-Weiß Koblenz | 30 | 11 | 7 | 12 | 36:40 | -4 | 40 |
| 12 |
|
VfR Aalen | 30 | 10 | 9 | 11 | 33:41 | -8 | 39 |
| 13 |
|
TSG Balingen | 30 | 10 | 8 | 12 | 38:37 | 1 | 38 |
| 14 |
|
Hessen Kassel | 30 | 10 | 8 | 12 | 42:53 | -11 | 38 |
| 15 |
|
FK Pirmasens | 30 | 8 | 12 | 10 | 28:45 | -17 | 36 |
| 16 |
|
FC Gießen | 30 | 8 | 11 | 11 | 31:35 | -4 | 35 |
| 17 |
|
1899 Hoffenheim II | 30 | 9 | 7 | 14 | 39:53 | -14 | 34 |
| 18 |
|
FC-Astoria Walldorf | 30 | 9 | 4 | 17 | 41:51 | -10 | 31 |
| 19 |
|
SG Sonnenhof Großaspach | 30 | 7 | 10 | 13 | 37:52 | -15 | 31 |
| 20 |
|
TSV Schott Mainz | 30 | 7 | 5 | 18 | 37:73 | -36 | 26 |
| 21 |
|
Bayern Alzenau | 30 | 5 | 7 | 18 | 36:62 | -26 | 22 |
| 22 |
|
Eintracht Stadtallendorf | 30 | 1 | 6 | 23 | 23:71 | -48 | 9 |
| Aufstieg | |
| Abstieg |
