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| 06.05.2022 | 19:00 | Viktoria Aschaffenburg | - | TSV 1860 Rosenheim | 3:1 (0:0) | |
| 19:00 | Wacker Burghausen | - | FC Memmingen | 3:0 (1:0) | ||
| 07.05.2022 | 14:00 | 1. FC Nürnberg II | - | VfB Eichstätt | 1:1 (0:0) | |
| 14:00 | 1. FC Schweinfurt 05 | - | SpVgg Bayreuth | 1:5 (1:1) | ||
| 14:00 | FC Augsburg II | - | SC Eltersdorf | 5:1 (3:1) | ||
| 14:00 | SpVgg Greuther Fürth II | - | FC Pipinsried | 3:0 (3:0) | ||
| 14:00 | SV Heimstetten | - | FV Illertissen | 1:0 (0:0) | ||
| 14:00 | TSV Aubstadt | - | Bayern München II | 0:1 (0:1) | ||
| 14:00 | TSV 1896 Rain | - | SV Schalding-Heining | 3:0 (1:0) | ||
| 17:00 | TSV Buchbach | - | SpVgg Unterhaching | 1:1 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SpVgg Bayreuth | 36 | 29 | 3 | 4 | 99:33 | 66 | 90 |
| 2 |
|
Bayern München II | 36 | 26 | 7 | 3 | 110:43 | 67 | 85 |
| 3 |
|
1. FC Schweinfurt 05 | 36 | 17 | 11 | 8 | 93:51 | 42 | 62 |
| 4 |
|
Wacker Burghausen | 36 | 18 | 7 | 11 | 78:51 | 27 | 61 |
| 5 |
|
SpVgg Unterhaching | 36 | 17 | 10 | 9 | 71:57 | 14 | 61 |
| 6 |
|
TSV Aubstadt | 36 | 16 | 10 | 10 | 63:39 | 24 | 58 |
| 7 |
|
FV Illertissen | 36 | 16 | 8 | 12 | 54:42 | 12 | 56 |
| 8 |
|
Viktoria Aschaffenburg | 36 | 13 | 9 | 14 | 50:49 | 1 | 48 |
| 9 |
|
1. FC Nürnberg II | 36 | 11 | 15 | 10 | 52:52 | 0 | 48 |
| 10 |
|
FC Augsburg II | 36 | 13 | 8 | 15 | 65:68 | -3 | 47 |
| 11 |
|
VfB Eichstätt | 36 | 12 | 11 | 13 | 47:60 | -13 | 47 |
| 12 |
|
TSV Buchbach | 36 | 11 | 12 | 13 | 44:42 | 2 | 45 |
| 13 |
|
SV Heimstetten | 36 | 13 | 5 | 18 | 53:65 | -12 | 44 |
| 14 |
|
FC Pipinsried | 36 | 12 | 6 | 18 | 46:68 | -22 | 42 |
| 15 |
|
TSV 1896 Rain | 36 | 12 | 6 | 18 | 38:64 | -26 | 42 |
| 16 |
|
FC Memmingen | 36 | 8 | 11 | 17 | 42:69 | -27 | 35 |
| 17 |
|
SC Eltersdorf | 36 | 10 | 5 | 21 | 51:82 | -31 | 35 |
| 18 |
|
SpVgg Greuther Fürth II | 36 | 8 | 10 | 18 | 43:67 | -24 | 34 |
| 19 |
|
SV Schalding-Heining | 36 | 7 | 8 | 21 | 33:71 | -38 | 29 |
| 20 |
|
TSV 1860 Rosenheim | 36 | 4 | 12 | 20 | 37:96 | -59 | 24 |
| Aufstieg | |
| Relegation | |
| Abstieg |
