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| 07.05.2021 | 20:00 | Sparta Rotterdam | - | Vitesse | 3:0 (1:0) | |
| 08.05.2021 | 16:30 | FC Twente | - | Heracles Almelo | 1:1 (0:0) | |
| 18:45 | sc Heerenveen | - | FC Utrecht | 0:0 (0:0) | ||
| 20:00 | AZ Alkmaar | - | Fortuna Sittard | 1:0 (1:0) | ||
| 21:00 | VVV-Venlo | - | RKC Waalwijk | 3:3 (2:2) | ||
| 09.05.2021 | 12:15 | FC Emmen | - | FC Groningen | 0:4 (0:1) | |
| 14:30 | Feyenoord | - | AFC Ajax | 0:3 (0:1) | ||
| 14:30 | PEC Zwolle | - | ADO Den Haag | 0:1 (0:1) | ||
| 16:45 | Willem II | - | PSV Eindhoven | 0:2 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AFC Ajax | 32 | 26 | 4 | 2 | 96:21 | 75 | 82 |
| 2 |
|
PSV Eindhoven | 32 | 20 | 8 | 4 | 69:32 | 37 | 68 |
| 3 |
|
AZ Alkmaar | 32 | 20 | 7 | 5 | 70:41 | 29 | 67 |
| 4 |
|
Vitesse | 32 | 18 | 6 | 8 | 48:32 | 16 | 60 |
| 5 |
|
Feyenoord | 32 | 15 | 10 | 7 | 60:35 | 25 | 55 |
| 6 |
|
FC Utrecht | 32 | 13 | 12 | 7 | 51:40 | 11 | 51 |
| 7 |
|
FC Groningen | 32 | 14 | 7 | 11 | 40:36 | 4 | 49 |
| 8 |
|
Sparta Rotterdam | 32 | 12 | 7 | 13 | 47:47 | 0 | 43 |
| 9 |
|
Heracles Almelo | 32 | 12 | 7 | 13 | 41:47 | -6 | 43 |
| 10 |
|
Fortuna Sittard | 32 | 12 | 4 | 16 | 46:53 | -7 | 40 |
| 11 |
|
sc Heerenveen | 32 | 9 | 12 | 11 | 41:44 | -3 | 39 |
| 12 |
|
FC Twente | 32 | 9 | 11 | 12 | 44:46 | -2 | 38 |
| 13 |
|
PEC Zwolle | 32 | 8 | 11 | 13 | 41:49 | -8 | 35 |
| 14 |
|
RKC Waalwijk | 32 | 6 | 9 | 17 | 31:51 | -20 | 27 |
| 15 |
|
Willem II | 32 | 6 | 7 | 19 | 34:66 | -32 | 25 |
| 16 |
|
FC Emmen | 32 | 5 | 9 | 18 | 33:67 | -34 | 24 |
| 17 |
|
VVV-Venlo | 32 | 6 | 5 | 21 | 42:84 | -42 | 23 |
| 18 |
|
ADO Den Haag | 32 | 4 | 10 | 18 | 26:69 | -43 | 22 |
| Champions League | |
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