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| 10.12.2021 | 20:00 | ADO Den Haag | - | AZ Alkmaar (J) | 3:2 (1:2) | |
| 20:00 | De Graafschap | - | Helmond Sport | 0:1 (0:0) | ||
| 20:00 | FC Eindhoven | - | Telstar | 1:1 (1:0) | ||
| 20:00 | SBV Excelsior | - | MVV | 2:1 (1:0) | ||
| 20:00 | FC Emmen | - | FC Dordrecht | 2:1 (0:0) | ||
| 20:00 | TOP Oss | - | Jong Ajax | 1:1 (0:0) | ||
| 20:00 | FC Volendam | - | Jong PSV | 3:2 (2:0) | ||
| 20:00 | NAC Breda | - | Almere City FC | 1:1 (0:0) | ||
| 20:00 | Roda JC Kerkrade | - | FC Den Bosch | 3:2 (2:2) | ||
| 20:00 | VVV-Venlo | - | FC Utrecht (J) | 1:2 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 19 | 12 | 6 | 1 | 47:25 | 22 | 42 |
| 2 |
|
SBV Excelsior | 19 | 13 | 2 | 4 | 47:25 | 22 | 41 |
| 3 |
|
FC Emmen | 19 | 11 | 3 | 5 | 29:15 | 14 | 36 |
| 4 |
|
Jong Ajax | 19 | 11 | 3 | 5 | 44:31 | 13 | 36 |
| 5 |
|
ADO Den Haag | 19 | 13 | 2 | 4 | 44:23 | 21 | 35 |
| 6 |
|
De Graafschap | 19 | 10 | 3 | 6 | 31:23 | 8 | 33 |
| 7 |
|
Roda JC Kerkrade | 19 | 8 | 6 | 5 | 37:27 | 10 | 30 |
| 8 |
|
FC Eindhoven | 19 | 9 | 3 | 7 | 33:27 | 6 | 30 |
| 9 |
|
NAC Breda | 19 | 7 | 6 | 6 | 31:23 | 8 | 27 |
| 10 |
|
FC Den Bosch | 19 | 8 | 1 | 10 | 22:34 | -12 | 25 |
| 11 |
|
VVV-Venlo | 19 | 7 | 2 | 10 | 21:25 | -4 | 23 |
| 12 |
|
MVV | 19 | 7 | 2 | 10 | 22:39 | -17 | 23 |
| 13 |
|
Jong PSV | 19 | 6 | 4 | 9 | 29:32 | -3 | 22 |
| 14 |
|
FC Utrecht (J) | 19 | 6 | 4 | 9 | 24:31 | -7 | 22 |
| 15 |
|
AZ Alkmaar (J) | 19 | 6 | 3 | 10 | 16:22 | -6 | 21 |
| 16 |
|
Telstar | 19 | 4 | 7 | 8 | 22:39 | -17 | 19 |
| 17 |
|
Almere City FC | 19 | 4 | 5 | 10 | 31:40 | -9 | 17 |
| 18 |
|
Helmond Sport | 19 | 5 | 4 | 10 | 17:29 | -12 | 16 |
| 19 |
|
TOP Oss | 19 | 3 | 6 | 10 | 20:31 | -11 | 15 |
| 20 |
|
FC Dordrecht | 19 | 2 | 4 | 13 | 22:48 | -26 | 10 |
| Aufstieg | |
| Playoffs | |
| Playoffs |
|
# ADO Den Haag: -6 P. # Helmond Sport: -3 P. |
