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| 04.05.2022 | 17:00 | FK Rabotnički | - | FK Borec | 2:1 (1:0) | |
| 17:00 | FK Skopje | - | FK Pelister | 4:2 (3:1) | ||
| 17:00 | GFK Tikvesh | - | FK Renova | 0:1 (0:1) | ||
| 17:00 | FC Struga | - | FK Bregalnica Štip | 1:0 (0:0) | ||
| 17:00 | KF Shkupi | - | Makedonija GP | 1:1 (0:0) | ||
| 17:00 | Akademija Pandev | - | KF Shkëndija 79 | 4:2 (2:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 31 | 22 | 6 | 3 | 63:21 | 42 | 72 |
| 2 |
|
Akademija Pandev | 31 | 18 | 7 | 6 | 53:28 | 25 | 61 |
| 3 |
|
KF Shkëndija 79 | 31 | 16 | 11 | 4 | 48:24 | 24 | 59 |
| 4 |
|
Makedonija GP | 31 | 17 | 6 | 8 | 44:39 | 5 | 57 |
| 5 |
|
FC Struga | 31 | 11 | 10 | 10 | 29:31 | -2 | 43 |
| 6 |
|
FK Renova | 31 | 10 | 12 | 9 | 35:28 | 7 | 42 |
| 7 |
|
FK Bregalnica Štip | 31 | 11 | 9 | 11 | 43:43 | 0 | 42 |
| 8 |
|
FK Rabotnički | 31 | 12 | 4 | 15 | 26:32 | -6 | 40 |
| 9 |
|
FK Skopje | 31 | 8 | 8 | 15 | 23:42 | -19 | 32 |
| 10 |
|
GFK Tikvesh | 31 | 8 | 7 | 16 | 34:36 | -2 | 31 |
| 11 |
|
FK Borec | 31 | 5 | 6 | 20 | 23:59 | -36 | 21 |
| 12 |
|
FK Pelister | 31 | 1 | 8 | 22 | 13:51 | -38 | 11 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
