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| 08.12.2021 | 13:00 | FK Bregalnica Štip | - | FK Rabotnički | 1:2 (0:0) | |
| 13:00 | FK Pelister | - | FK Borec | 1:3 (1:1) | ||
| 13:00 | KF Shkupi | - | KF Shkëndija 79 | 1:1 (0:0) | ||
| 13:00 | FK Skopje | - | FC Struga | 1:0 (0:0) | ||
| 13:00 | Makedonija GP | - | Akademija Pandev | 4:1 (2:0) | ||
| 13:00 | FK Renova | - | GFK Tikvesh | 1:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 17 | 12 | 3 | 2 | 40:11 | 29 | 39 |
| 2 |
|
Akademija Pandev | 17 | 9 | 5 | 3 | 27:18 | 9 | 32 |
| 3 |
|
KF Shkëndija 79 | 17 | 8 | 7 | 2 | 27:14 | 13 | 31 |
| 4 |
|
FK Renova | 17 | 7 | 6 | 4 | 25:15 | 10 | 27 |
| 5 |
|
FK Bregalnica Štip | 17 | 7 | 5 | 5 | 24:24 | 0 | 26 |
| 6 |
|
Makedonija GP | 17 | 7 | 3 | 7 | 25:30 | -5 | 24 |
| 7 |
|
FC Struga | 17 | 5 | 8 | 4 | 13:14 | -1 | 23 |
| 8 |
|
FK Rabotnički | 17 | 6 | 4 | 7 | 12:17 | -5 | 22 |
| 9 |
|
FK Skopje | 17 | 5 | 5 | 7 | 13:21 | -8 | 20 |
| 10 |
|
GFK Tikvesh | 17 | 3 | 6 | 8 | 15:20 | -5 | 15 |
| 11 |
|
FK Borec | 17 | 3 | 3 | 11 | 16:31 | -15 | 12 |
| 12 |
|
FK Pelister | 17 | 0 | 5 | 12 | 6:28 | -22 | 5 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
