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| 17.04.2021 | 13:00 | FK Renova | - | Sileks Kratovo | 2:1 (2:0) | |
| 18.04.2021 | 13:00 | Akademija Pandev | - | Vardar Skopje | 3:0 (3:0) | |
| 13:00 | FK Belasica | - | KF Shkëndija 79 | 0:3 (0:2) | ||
| 13:00 | FK Borec | - | KF Shkupi | 0:1 (0:0) | ||
| 13:00 | FK Rabotnički | - | Makedonija GP | 2:2 (2:2) | ||
| 13:00 | FC Struga | - | FK Pelister | 3:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 28 | 19 | 8 | 1 | 56:16 | 40 | 65 |
| 2 |
|
KF Shkupi | 28 | 15 | 7 | 6 | 38:23 | 15 | 52 |
| 3 |
|
Makedonija GP | 28 | 14 | 6 | 8 | 43:36 | 7 | 48 |
| 4 |
|
FC Struga | 28 | 11 | 11 | 6 | 32:22 | 10 | 44 |
| 5 |
|
FK Rabotnički | 28 | 9 | 14 | 5 | 35:29 | 6 | 41 |
| 6 |
|
FK Pelister | 28 | 9 | 8 | 11 | 28:34 | -6 | 35 |
| 7 |
|
Akademija Pandev | 28 | 10 | 4 | 14 | 23:28 | -5 | 34 |
| 8 |
|
FK Borec | 28 | 9 | 6 | 13 | 25:29 | -4 | 33 |
| 9 |
|
FK Renova | 28 | 7 | 10 | 11 | 31:40 | -9 | 31 |
| 10 |
|
Sileks Kratovo | 28 | 8 | 5 | 15 | 41:37 | 4 | 29 |
| 11 |
|
Vardar Skopje | 28 | 6 | 10 | 12 | 30:52 | -22 | 28 |
| 12 |
|
FK Belasica | 28 | 4 | 5 | 19 | 21:57 | -36 | 17 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
