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| H | CF América | - | CF Pachuca | 3:1 (2:1) | ||
| R | CF Pachuca | - | CF América | 1:4 (0:2) | ||
| H: 20.11.2024 16:00 | R: 23.11.2024 16:30 | Sieger: CF América | ||||
| H | Deportivo Toluca | - | Atlético San Luis | 1:1 (0:1) | ||
| R | Atlético San Luis | - | Deportivo Toluca | 0:0 (0:0) | ||
| H: 20.11.2024 16:00 | R: 24.11.2024 01:00 | Sieger: Atlético San Luis | ||||
| H | Deportivo Guadalajara | - | UANL Tigres | 1:1 (0:0) | ||
| R | UANL Tigres | - | Deportivo Guadalajara | 2:0 (0:0) | ||
| H: 20.11.2024 19:00 | R: 23.11.2024 16:00 | Sieger: UANL Tigres | ||||
| H | FC Juárez | - | Cruz Azul | 0:0 (0:0) | ||
| R | Cruz Azul | - | FC Juárez | 2:3 (1:2) | ||
| H: 21.11.2024 17:00 | R: 24.11.2024 16:00 | Sieger: FC Juárez | ||||
