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| H | CF América | - | Pumas UNAM | 1:0 (1:0) | ||
| R | Pumas UNAM | - | CF América | 0:1 (0:1) | ||
| H: 23.04.2025 18:00 | R: 26.04.2025 18:00 | Sieger: CF América | ||||
| H | Santos Laguna | - | UANL Tigres | 2:2 (1:1) | ||
| R | UANL Tigres | - | Santos Laguna | 3:1 (1:0) | ||
| H: 24.04.2025 17:00 | R: 27.04.2025 17:00 | Sieger: UANL Tigres | ||||
| H | Atlas Guadalajara | - | Deportivo Toluca | 2:2 (1:1) | ||
| R | Deportivo Toluca | - | Atlas Guadalajara | 3:1 (1:1) | ||
| H: 24.04.2025 17:00 | R: 27.04.2025 17:00 | Sieger: Deportivo Toluca | ||||
| H | Deportivo Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| R | CF Pachuca | - | Deportivo Guadalajara | 2:3 (1:2) | ||
| H: 24.04.2025 18:00 | R: 27.04.2025 18:00 | Sieger: Deportivo Guadalajara | ||||
