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| H | CF América | - | Deportivo Toluca | 1:1 (0:0) | ||
| R | Deportivo Toluca | - | CF América | 0:1 (0:1) | ||
| H: 13.10.2022 16:00 | R: 16.10.2022 18:30 | Sieger: CF América | ||||
| H | Atlas Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| R | CF Pachuca | - | Atlas Guadalajara | 2:0 (1:0) | ||
| H: 13.10.2022 16:00 | R: 16.10.2022 16:00 | Sieger: CF Pachuca | ||||
