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| 22.10.2022 | 16:00 | Pumas UNAM | - | Puebla FC | 1:1 (1:1) | |
| 16:00 | Deportivo Toluca | - | Gallos Blancos | 1:1 (1:1) | ||
| 16:00 | UANL Tigres | - | Club León | 1:1 (0:1) | ||
| 16:00 | Santos Laguna | - | Club Tijuana | 0:1 (0:0) | ||
| 16:00 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:2 (0:2) | ||
| 16:00 | Club Necaxa | - | Cruz Azul | 1:1 (0:0) | ||
| 18:00 | CF Pachuca | - | CF América | 1:2 (1:2) | ||
| 19:30 | Mazatlán FC | - | CF Monterrey | 2:2 (1:2) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 16 | 8 | 3 | 5 | 41:29 | 12 | 27 |
| 2 |
|
Club Necaxa | 16 | 7 | 5 | 4 | 38:25 | 13 | 26 |
| 3 |
|
Cruz Azul | 16 | 7 | 5 | 4 | 36:25 | 11 | 26 |
| 4 |
|
CF América | 16 | 7 | 4 | 5 | 29:27 | 2 | 25 |
| 5 |
|
Pumas UNAM | 16 | 6 | 5 | 5 | 19:21 | -2 | 23 |
| 6 |
|
CF Pachuca | 16 | 7 | 1 | 8 | 25:25 | 0 | 22 |
| 7 |
|
Gallos Blancos | 16 | 6 | 3 | 7 | 19:30 | -11 | 21 |
| 8 |
|
FC Juárez | 16 | 4 | 6 | 6 | 21:27 | -6 | 18 |
| 9 |
|
Puebla FC | 16 | 2 | 4 | 10 | 21:40 | -19 | 10 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 16 | 12 | 3 | 1 | 34:16 | 18 | 39 |
| 2 |
|
Santos Laguna | 16 | 11 | 1 | 4 | 30:13 | 17 | 34 |
| 3 |
|
CF Monterrey | 16 | 8 | 3 | 5 | 36:22 | 14 | 27 |
| 4 |
|
Atlas Guadalajara | 16 | 7 | 3 | 6 | 23:18 | 5 | 24 |
| 5 |
|
Mazatlán FC | 16 | 7 | 3 | 6 | 21:26 | -5 | 24 |
| 6 |
|
UANL Tigres | 16 | 6 | 2 | 8 | 20:22 | -2 | 20 |
| 7 |
|
Club Tijuana | 16 | 5 | 2 | 9 | 17:28 | -11 | 17 |
| 8 |
|
Atlético San Luis | 16 | 4 | 4 | 8 | 22:31 | -9 | 16 |
| 9 |
|
Club León | 16 | 0 | 3 | 13 | 20:47 | -27 | 3 |
| Playoffs | |
| Playoffs |
