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| H | CF Pachuca | - | Deportivo Guadalajara | 2:1 (0:0) | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| H: 09.12.2021 01:00 | R: 11.12.2021 17:00 | Sieger: Deportivo Guadalajara | ||||
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| H | CF Pachuca | - | Deportivo Guadalajara | 2:1 (0:0) | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| H: 09.12.2021 01:00 | R: 11.12.2021 17:00 | Sieger: Deportivo Guadalajara | ||||
