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| H | Tritones Vallarta | - | Mazorqueros | 1:2 (1:1) | ||
| R | Mazorqueros | - | Tritones Vallarta | 5:4 (0:1, 0:1) i.E. | ||
| H: 27.04.2022 23:30 | R: 01.05.2022 00:30 | Sieger: Mazorqueros | ||||
| H | Cafetaleros de Chiapas | - | Inter Playa | 0:0 (0:0) | ||
| R | Inter Playa | - | Cafetaleros de Chiapas | 0:1 (0:0) | ||
| H: 28.04.2022 03:00 | R: 30.04.2022 23:00 | Sieger: Cafetaleros de Chiapas | ||||
